Table 2 GRADE summary of findings
Certainty assessment | № of patients | Effect | Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
№ of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Deep anesthesia | Light anesthesia | Relative (95% CI) | Absolute (95% CI) | ||
POD | ||||||||||||
4 | randomised trials | not serious | very seriousa | not serious | not serious | none | 150/454 (33.0%) | 111/438 (25.3%) | OR 1.40 (0.63 to 3.08) | 69 more per 1,000 (from 77 fewer to 258 more) | ⨁⨁◯◯ Low | CRITICAL |
Cognitive function 3 months or more after surgery | ||||||||||||
3 | randomised trials | not serious | not serious | not serious | not serious | none | 35/325 (10.8%) | 29/303 (9.6%) | OR 1.13 (0.67 to 1.91) | 11 more per 1,000 (from 29 fewer to 72 more) | ⨁⨁⨁⨁ High | CRITICAL |
Mortality 3 months or more after surgery | ||||||||||||
3 | randomised trials | not serious | not serious | not serious | not serious | none | 253/3480 (7.3%) | 227/3469 (6.5%) | OR 1.12 (0.93 to 1.35) | 7 more per 1,000 (from 4 fewer to 21 more) | ⨁⨁⨁⨁ High | CRITICAL |