Table 3 Optimal cutoffs with associated specificity, sensitivity and youden index (and 95% Confidence Intervals (CI)) for follow-up times 2 and 4 years

TUGdt-NA, animals/10 s

2

4.0 (3.1–5.2)

0.74 (0.52–0.93)

0.79 (0.55–0.98)

0.53 (0.40–0.66)

4

4.5 (3.7–5.4)

0.65 (0.51–0.83)

0.64 (0.51–0.82)

0.29 (0.13–0.44)

TUGdt-MB, months/10 s

2

4.6 (3.3–5.5)

0.62 (0.50–0.80)

0.71 (0.52–0.88)

0.33 (0.17–0.48)

4

4.7 (3.6–5.6)

0.61 (0.50–0.79)

0.65 (0.51–0.83)

0.26 (0.09–0.42)

MMSE score

2

27 (26–28)

0.72 (0.53–0.87)

0.74 (0.55–0.92)

0.46 (0.32–0.60)

4

27 (26–28)

0.77 (0.59–0.94)

0.69 (0.51–0.86)

0.46 (0.31–0.59)

Verbal Fluency score

2

17 (16–19)

0.66 (0.54–0.76)

0.84 (0.71–0.95)

0.50 (0.36–0.63)

4

18 (16–19)

0.66 (0.51–0.81)

0.67 (0.52–0.84)

0.33 (0.17–0.48)