Table 2 Summary of drugs scored 1-3 and extracted from the existing scales and drugs added by the expert group
From: Development of the Swedish anticholinergic burden scale (Swe-ABS)
Drug | ATC code | Han [32] | Ancelin [31] | Carnahan [30] | Boustani [34] | Rudolph [35] | Ehrt [22] | Sittironnarit [33] | Kiesel [18] | Jun [19] | Duran [17] |
|---|---|---|---|---|---|---|---|---|---|---|---|
Alimemazine* | R06AD01 | Â | 2 | Â | 1 | Â | 0 | Â | Â | 1 | Low |
Alprazolam | N05BA12 | 1 | 3 | 1 | 1 | Â | Â | 1 | 1 | 1 | Disc (high) |
Amantadine | N04BB01 | Â | Â | 1 | 2 | 2 | Â | Â | 2 | 2 | Low |
Amitriptyline* | N06AA09 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | High |
Ampicillin | J01CA01 | Â | Â | 1 | Â | Â | Â | Â | 1 | 0 | Disc (low) |
Aripiprazole | N05AX12 | Â | Â | Â | 1 | Â | Â | 0 | 1 | 1 | Â |
Asenapine | N05AH05 | Â | Â | Â | 1 | Â | Â | Â | 1 | Â | Â |
Atenolol | C07AB03 | 1 | Â | 0 | 1 | Â | 0 | 0 | 1 | 0 | 0 |
Atropine* | A03BA01 | 3 | Â | 3 | 3 | 3 | Â | 3 | 3 | 3 | High |
Azathioprine | L04AX01 | Â | Â | 1 | Â | Â | Â | Â | 1 | 0 | Disc (low) |
Baclofen | M03BX01 | 2 | Â | 0 | Â | 2 | Â | Â | 1 | 1 | Low |
Biperiden* | N04AA02 | Â | Â | Â | Â | Â | Â | Â | Â | 3 | Â |
Bisacodyl | A06AB02 | Â | Â | 0 | Â | Â | Â | 1 | 1 | 0 | Disc (low) |
Bromocriptine | G02CB01 | Â | Â | 1 | Â | Â | 0 | Â | 1 | 0 | Low |
Bupropion | N06AX12 | 1 | Â | 0 | 1 | Â | Â | Â | 1 | 1 | Disc (low) |
Captopril | C09AA01 | Â | Â | 1 | 1 | Â | 0 | 0 | 1 | 0 | Disc (low) |
Carbamazepine | N03AF01 | 1 | Â | 2 | 2 | Â | 0 | 0 | 2 | 1 | Low |
Celecoxib | M01AH01 | Â | Â | 0 | Â | Â | Â | 1 | 1 | 0 | Disc (low) |
Cetirizine | R06AE07 | 2 | Â | 0 | 1 | 2 | Â | 2 | 1 | 1 | Low |
Chlorprothixene* | N05AF03 | Â | Â | Â | Â | Â | 0 | Â | Â | 3 | Â |
Chlorthalidone | C03BA04 | Â | Â | 1 | 1 | Â | Â | 0 | 1 | 0 | Disc (low) |
Chlorzoxazone | M03BB03 | Â | Â | 0 | Â | Â | Â | Â | Â | 0 | Â |
Ciclosporin | L04AD01 | Â | Â | 1 | Â | Â | Â | Â | 1 | 0 | Disc (low) |
Cinnarizine | N07CA02 | Â | Â | Â | Â | Â | Â | Â | Â | 1 | Â |
Citalopram | N06AB04 | Â | Â | 0 | Â | Â | 1 | 1 | 1 | 1 | Low |
Clemastine* | R06AA04 | Â | Â | 3 | 3 | Â | Â | Â | 3 | 3 | High |
Clindamycin | J01FF01 | Â | Â | 1 | Â | Â | Â | Â | 1 | 0 | Disc (low) |
Clomipramine* | N06AA04 | Â | 3 | 3 | 3 | Â | Â | Â | 3 | 3 | High |
Clonazepam | N03AE01 | Â | Â | 1 | Â | Â | Â | 1 | 1 | 1 | Low |
Clozapine* | N05AH02 | Â | Â | 3 | 3 | 2 | 3 | Â | 3 | 3 | High |
Codeine | R05DA04 | 1 | 2 | 1 | 1 | Â | 0 | 1 | 1 | 1 | Low |
Colchicine | M04AC01 | Â | 3 | 0 | 1 | Â | Â | 0 | Â | 0 | Disc (high) |
Darifenacin* | G04BD10 | Â | Â | 3 | 3 | Â | Â | Â | 3 | Â | High |
Desloratadine | R06AX27 | Â | Â | Â | 1 | Â | Â | Â | 1 | 1 | Â |
Dexamethasone | H02AB02 | Â | Â | 1 | Â | Â | Â | 0 | 1 | 0 | Disc (low) |
Diazepam | N05BA01 | 1 | Â | 1 | 1 | Â | 1 | 1 | 1 | 1 | Low |
Digoxin | C01AA05 | Â | 3 | 1 | 1 | Â | 1 | 1 | 1 | 1 | Disc (high) |
Diltiazem | C08DB01 | Â | Â | 1 | Â | Â | Â | 0 | 1 | 0 | Disc (low) |
Dimenhydrinate* | R06AA02 | Â | Â | 3 | 3 | Â | Â | Â | 3 | 3 | High |
Diphenhydramine | R05CA10 | 3 | Â | 3 | 3 | 3 | Â | Â | 3 | 3 | High |
Dipyridamole | B01AC07 | Â | Â | 1 | 1 | Â | 0 | Â | 1 | 0 | Disc (low) |
Domperidone | A03FA03 | Â | Â | Â | Â | Â | Â | 1 | 1 | 0 | Low |
Entacapone | N04BX02 | Â | Â | 0 | Â | 1 | Â | Â | 1 | 0 | Low |
Escitalopram | N06AB10 | Â | Â | 0 | Â | Â | Â | 1 | 1 | 1 | Disc (low) |
Etoricoxib | M01AH05 | Â | Â | Â | Â | Â | Â | Â | 1 | Â | Â |
Famotidine | A02BA03 | Â | Â | 1 | Â | Â | Â | 0 | 1 | 0 | Disc (low) |
Fentanyl | N02AB03 | Â | Â | 1 | 1 | Â | Â | 0 | 1 | 1 | Low |
Fesoterodine* | G04BD11 | Â | Â | Â | 3 | Â | Â | Â | 3 | 3 | Â |
Fexofenadine | R06AX26 | 2 | Â | 0 | 0 | Â | Â | 2 | 1 | 0 | Low |
Fluoxetine | N06AB03 | 1 | Â | 1 | Â | Â | 1 | 1 | 1 | 1 | Low |
Flupentixol | N05AF01 | Â | Â | Â | Â | Â | Â | Â | Â | 1 | Â |
Fluvoxamine | N06AB08 | Â | Â | 1 | 1 | Â | 1 | 1 | 1 | 1 | Low |
Furosemide | C03CA01 | Â | 3 | 1 | 1 | Â | 1 | Â | 1 | 1 | Disc (high) |
Gentamicin | J01GB03 | Â | Â | 1 | Â | Â | Â | Â | 1 | 0 | Disc (low) |
Glycopyrroniuminj* | A03AB02 | Â | Â | Â | Â | Â | Â | Â | Â | 2 | Â |
Guaifenesin | R05CA03 | 1 | Â | 0 | Â | Â | Â | Â | 1 | 1 | Discr (low) |
Haloperidol | N05AD01 | Â | Â | 0 | 1 | 1 | 0 | 2 | 2 | 1 | Low |
Hydralazine | C02DB02 | Â | Â | 1 | 1 | Â | Â | 0 | 1 | 1 | Disc (low) |
Hydrocortisone | H02AB09 | Â | Â | 1 | 1 | Â | Â | 0 | 1 | 1 | Disc (low) |
Hydroxyzine* | N05BB01 | Â | 3 | 3 | 3 | 3 | Â | Â | 3 | 3 | High |
Hyoscyamine* | A03BA03 | Â | Â | 3 | 3 | 3 | Â | Â | Â | 3 | High |
Isosorbide mononitrate | C01DA14 | Â | Â | 1 | Â | Â | Â | 0 | 1 | Â | Disc (low) |
Ketorolac | M01AB15 | 1 | Â | Â | Â | Â | Â | Â | 1 | 0 | Low |
Lansoprazole | A02BC03 | Â | Â | 0 | Â | Â | 1 | 0 | 1 | 0 | Disc (low) |
Levodopa | N04BA01 | 1 | Â | 0 | Â | 1 | Â | 1 | 1 | Â | 0 |
Levomepromazine* | N05AA02 | Â | 3 | 2 | 2 | Â | Â | Â | 3 | 2 | High |
Lithium | N05AN01 | Â | Â | 0 | Â | Â | Â | 1 | 1 | 0 | Low |
Loperamide | A07DA03 | 1 | Â | 1 | 1 | 2 | Â | 1 | 2 | 1 | Low |
Loratadine | R06AX13 | 1 | Â | 0 | 1 | 2 | Â | 1 | 1 | 1 | Low |
Lorazepam | N05BA06 | Â | Â | 1 | Â | Â | Â | Â | 1 | 1 | Disc (low) |
Meclizine* | R06AE05 | Â | Â | 3 | 3 | 3 | Â | Â | Â | 3 | High |
Melperone | N05AD03 | Â | Â | Â | Â | Â | 0 | Â | 0 | Â | Â |
Memantine | N06DX01 | Â | Â | Â | Â | Â | Â | 0 | 0 | 0 | Â |
Metformin | A10BA02 | Â | Â | 0 | Â | Â | Â | 1 | 1 | 0 | Disc (low) |
Methadone | N07BC02 | 2 | Â | Â | Â | Â | Â | Â | 2 | Â | Low |
Methotrexate | L04AX03 | Â | Â | 0 | Â | Â | Â | 1 | 1 | 0 | Disc (low) |
Methylprednisolone | H02AB04 | Â | Â | 1 | Â | Â | Â | 0 | 1 | 0 | Disc (low) |
Metoclopramide | A03FA01 | 3 | Â | 0 | Â | 1 | 0 | 1 | 1 | 0 | Disc (high) |
Metoprolol | C07AB02 | 1 | Â | 0 | 1 | Â | 0 | 0 | 1 | 0 | 0 |
Midazolam | N05CD08 | Â | Â | 1 | Â | Â | Â | Â | 1 | 1 | Disc (low) |
Mirtazapine | N06AX11 | Â | Â | 0 | Â | 1 | Â | Â | 1 | 1 | Low |
Morphine | N02AA01 | 1 | Â | 1 | 1 | Â | Â | Â | 1 | 1 | Low |
Naratriptan | N02CC02 | Â | Â | Â | Â | Â | Â | 1 | 1 | 0 | Disc (low) |
Nifedipine | C08CA05 | Â | Â | 1 | 1 | Â | 0 | 0 | 1 | 0 | 0 |
Nortriptyline* | N06AA10 | 3 | Â | 3 | 3 | 2 | 2 | Â | 3 | 3 | High |
Olanzapine | N05AH03 | 1 | Â | 1 | 3 | 2 | 2 | Â | 2 | 3 | Low |
Orphenadrine* | M03BC01 | Â | 3 | 3 | 3 | Â | 3 | Â | 3 | 3 | High |
Oxazepam | N05BA04 | Â | Â | 1 | Â | Â | 0 | 1 | 1 | Â | Disc (low) |
Oxcarbazepine | N03AF02 | Â | Â | 2 | 2 | Â | Â | Â | 2 | 2 | Low |
Oxybutynin* | G04BD04 | Â | 3 | 3 | 3 | 3 | 3 | 2 | 3 | 3 | High |
Oxycodone | N02AA05 | 1 | Â | 1 | Â | Â | Â | 1 | 1 | 1 | Low |
Paliperidone | N05AX13 | Â | Â | Â | 1 | Â | Â | Â | 1 | 1 | Â |
Paroxetine | N06AB05 | 2 | Â | 1 | 3 | 1 | 2 | 2 | 2 | 2 | Low |
Perphenazine | N05AB03 | 2 | Â | 1 | 3 | 3 | 0 | Â | 1 | 2 | Disc (high) |
Pethidine | N02AB02 | Â | Â | 2 | 2 | Â | 0 | Â | 2 | 2 | Low |
Phenobarbital | N03AA02 | 1 | Â | 0 | Â | Â | 1 | Â | 1 | 0 | Disc (low) |
Piperacillin | J01CA12 | Â | Â | 1 | Â | Â | Â | Â | 1 | 0 | Disc (low) |
Pramipexole | N04BC05 | Â | Â | 0 | Â | 1 | 0 | Â | 1 | 0 | Disc (low) |
Prednisolone | H02AB06 | Â | Â | 1 | Â | Â | 0 | 0 | 1 | 1 | Disc (low) |
Prochlorperazine* | N05AB04 | 2 | Â | 1 | Â | 2 | 0 | 2 | Â | Â | Low |
Promethazine* | R06AD02 | Â | Â | 3 | 3 | 3 | Â | 0 | 1 | Â | High |
Propiomazine | N05CM06 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Quetiapine | N05AH04 | 2 | Â | 0 | 3 | 1 | 1 | Â | 2 | 2 | Low |
Ranitidine | A02BA02 | 2 | Â | 2 | 1 | 1 | 1 | 1 | 2 | 1 | Low |
Risperidone | N05AX08 | 1 | Â | 0 | 1 | 1 | Â | 1 | 1 | 1 | Low |
Rotigotinepatch | N04BC09 | Â | Â | Â | Â | Â | Â | Â | 1 | Â | Â |
Scopolamine* | A04AD01 | 3 | Â | 3 | 3 | Â | Â | Â | 3 | 3 | High |
Selegiline | N04BD01 | Â | Â | 0 | Â | 1 | 0 | Â | 1 | 0 | Disc (low) |
Sertindole | N05AE03 | Â | Â | Â | Â | Â | Â | Â | Â | 0 | Â |
Sertraline | N06AB06 | 1 | Â | 1 | Â | Â | 0 | 0 | 1 | 0 | 0 |
Solifenacin* | G04BD08 | Â | Â | Â | 3 | Â | Â | 0 | 3 | 3 | Â |
Sumatriptan | N02CC01 | Â | Â | Â | Â | Â | Â | 1 | 1 | 0 | Disc (low) |
Theophylline | R03DA04 | Â | 2 | 1 | 1 | Â | 1 | 2 | 2 | 1 | Low |
Tolterodine* | G04BD07 | 3 | Â | 3 | 3 | 2 | Â | 3 | 3 | 3 | High |
Tramadol | N02AX02 | 2 | Â | 1 | Â | Â | Â | 2 | 2 | 2 | Low |
Triamcinolone | H02AB08 | Â | Â | 1 | Â | Â | Â | 0 | 1 | 0 | Disc (low) |
Valproic acid | N03AG01 | Â | Â | 1 | Â | Â | Â | 0 | 1 | 0 | Disc (low) |
Vancomycin | J01XA01 | Â | Â | 1 | Â | Â | Â | Â | 1 | 0 | Disc (low) |
Venlafaxine | N06AX16 | 1 | Â | 0 | 1 | Â | 0 | 1 | 1 | 1 | 0 |
Vortioxetine | N06AX26 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Warfarin | B01AA03 | Â | Â | 1 | 1 | Â | 0 | 0 | 1 | 0 | 0 |
Ziprasidone | N05AE04 | Â | Â | Â | Â | 1 | Â | Â | 1 | 1 | Disc (low) |
Zolmitriptan | N02CC03 | Â | Â | Â | Â | Â | Â | 1 | 1 | 0 | Disc (low) |
Zuclopenthixol | N05AF05 | Â | Â | Â | Â | Â | Â | Â | Â | 2 | Â |