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Table 2 Modelled intervention outcomesa

From: The OptimaMed intervention to reduce medication burden in nursing home residents with severe dementia: results from a pragmatic, controlled study

 

Intervention NHs (n = 59)

Control NHs (n = 64)

 

Medication use

Study beginning

End of follow-up

p-vvalue**

Study beginning

End of follow-up

p-vvalue**

p-vvalue***

Total number of regular medications (n)

416

389

 

492

369

  

Number of all medications per participant (mean ± SE)

8.15 ± 0.76

7.76 ± 0.73

0.28

10.73 ± 1.04

9.17 ± 0.91

0.0001

0.0806

Number of regular medications per participant (mean ± SE)

7.06 ± 0.45

6.60 ± 0.43

0.2126

7.69 ± 0.45

5.90 ± 0.40

 < 0.0001

0.0092

Total number of regular “generally appropriate” medications (n)

140

127

 

156

121

  

Total number of regular “sometimes appropriate” medications (n)

284

265

 

313

241

  

Total number of regular “exceptionally appropriate” medications (n)

13

13

 

24

19

  

Proportion of participants using regular “generally appropriate” medications (%)

86

81

0.4438

88

76

0.4583

0.9464

Proportion of participants using regular “sometimes appropriate” medications (%)

98

100

0.0917

98

98

0.1201

0.2770

Proportion of participants using regular “exceptionally appropriate” medications (%)

19

17

0.4331

28

21

0.0069

0.2168

Total number of residents with regular antipsychotics (n)a

38

34

 

25

19

  

Number of regular antipsychotics per participant (mean ± SE)a

0.64 ± 0.09

0.58 ± 0.09

0.2141

0.39 ± 0.07

0.30 ± 0.06

0.0199

0.2687

CMAI (mean ± SE)

38.8 ± 1.4

35.6 ± 1.5

0.0002

36.0 ± 1.5

35.5 ± 1.5

0.5267

0.0262

PACSLAC-F short version (mean ± SE, range)

4.91 ± 0.41

4.29 ± 0.44

0.0577

4.06 ± 0.40

4.34 ± 0.44

0.3783

0.0487

  1. SD Standard deviation
  2. aRepeated measures, adjusted for random NH effect (difference in difference test)
  3. **p-values for pre-post comparison
  4. ***p-values for change in time group comparison