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Table 3 Medication outcomes of included studies

From: Outcomes in deprescribing implementation trials and compliance with expert recommendations: a systematic review

Authors

Medication outcomes

Aharaz A. [22]

Differences in deprescribing rates for patients in the intervention versus control group with > 1 medication deprescribed

Change in total number of medications

Percentage of deprescribed medications and sustained

Ashworth N. [23]

Mean number of older patients prescribed high dose of BZD

Mean defined daily dose of BZD

Balsom C. [24]

Change in the number of prescribed regular and as-needed medications

Campbell NL. [27]

Proportion of anticholinergic orders prescribed as discontinuation orders in the preintervention and postintervention periods

Population prevalence of anticholinergic use

Cateau D. [28]

Number of PIMs used

Number of chronic drugs

Number of inappropriate defined daily dose

Number of chronic defined daily dose

Cateau D. [29]

Proportion of galenic units considered potentially inappropriate at the follow up

Number of PIMs per day (defined daily dose)

Number of PIMs per resident (defined daily dose/resident)

Number of defined daily dose/resident to avoid and to reevaluate

Clyne B. [30]

Proportion of patients with PIP and mean of PIP

Cool C. [31]

Potentially inappropriate drug prescribing

Curtin D. [32]

Mean change in the number of long term prescribed medicines

Changes in prescription of neuroleptic, antipsychotic medications

Dalleur O. [33]

Proportion of PIMs discontinued

Edey R. [34]

Number of discontinued home medications at hospital discharge

Proportion of medication remaining deprescribing at 30 days after discharge

Eveleigh R. [35]

Proportion of patients discontinuation ATD

Gedde MH. [36]

Mean change in numbers of prescribed psychotropic drugs

Gulla C. [38]

Number of antihypertensive drugs

Hah JM. [39]

Time to baseline opioid use

Time to complete opioid cessation

Ee C.[40]

Reduction in the total number of medications

Needs for deprescribed medications to be restarted or initiation of new symptomatic control medications after deprescribing

Kua CH. [42]

Pill burden

Kuntz JL. [43]

Discontinuation of BZD-related drugs

Number of Z-drug dispensing

Navy HJ. [44]

Composite criteria:

- Rate of patients who had no alprazolam dispensing

- Rate of patients who had an alprazolam dose reduction

- Rate of patients who interchanged to an alternate medication

Potter K. [45]

Mean change in drugs number

Mean change in drugs number

Rieckert A. [46]

Number of drugs prescribed

Smeets CHW. [48]

Prescription of psychotropic drugs

Sullivan MD. [49]

Mean daily opioid dose in the past week at 22 weeks after randomization

Opioid dose 34 weeks after randomization

Percent reduction from baseline in opioid dose

Tannenbaum C. [50]

Complete cessation of BZD

Dose reduction of BZD

Tseng ES. [51]

Opioid use on the day prior to discharge

Percentage of patients who were discharged with prescriptions for opioid or ancillary medications

Morphine equivalent doses prescribed at discharge

Late prescription and morphine equivalent doses at 30 days

Van der Meer HG. [52]

Difference in proportion of patients having a decrease of DBI > 0,5

Vicens C. [53]

Discontinuation BZD

Vicens C. [54]

BZD cessation

Wong APY. [55]

Percentage reduction of total daily dose of PIMs

Percentage reduction of total number of medicine of PIMS

Medicine reinitialization or substitution

Wouters H. [56]

Proportion of resident who successfully discontinued use of at least 1 inappropriate medication

Number of residents for whom at least 1 underprescribing medication was initiated at least 1 dose was adjusted, and at least 1 potentially hazardous drug was replaced by a safer alternative

Cumulative exposure to anticholinergic and sedative drugs

Zechmann S. [57]

Mean difference in the number of drugs per person

Number of drug change recommendations and kind of change

Number of DPP taken without the GP knowledge at pre intervention

  1. Legend: primary outcomes are in bold.
  2. Abbreviations: ATD Antidepressants, BZD Benzodiazepines, DBI Drug burden index, DPP Drugs per person, GP General practitioner, PIMs Potentially inappropriate medications, PIP Potentially inappropriate prescribing