Table 4 Odds ratios of FRIs associated medication use in older adults: case-crossover design
Medication class | Subclass of the study medications | Exposed only in the hazard period, n = 94,332 | Exposed only in the control period, n = 94,332 | Crude OR | 95%CI | |||
|---|---|---|---|---|---|---|---|---|
N | % | N | % | Lower | Upper | |||
Cardiovascular | Angiotensin II antagonists | 2,148 | 2.3% | 1,216 | 1.3% | 1.96 | 1.79 | 2.15 |
Beta-blocking agents | 1,089 | 1.2% | 1,171 | 1.2% | 0.92 | 0.82 | 1.03 | |
Calcium channel blockers | 2,231 | 2.4% | 1,698 | 1.8% | 1.38 | 1.27 | 1.50 | |
Diuretics | 2,207 | 2.3% | 2,127 | 2.3% | 1.04 | 0.97 | 1.13 | |
Antithrombotic agents | 2,204 | 2.3% | 1,530 | 1.6% | 1.54 | 1.41 | 1.67 | |
Lipid-modifying agents | 2,370 | 2.5% | 1,727 | 1.8% | 1.46 | 1.34 | 1.58 | |
Nervous system | Antipsychotics | 420 | 0.4% | 242 | 0.3% | 1.84 | 1.51 | 2.25 |
Antidepressants | 2,110 | 2.2% | 1,581 | 1.7% | 1.37 | 1.26 | 1.49 | |
Anxiolytics | 7,010 | 7.4% | 6,159 | 6.5% | 1.15 | 1.10 | 1.20 | |
Hypnotics and sedatives | 1,283 | 1.4% | 1,066 | 1.1% | 1.22 | 1.10 | 1.35 | |
Opioids | 7,642 | 8.1% | 5,015 | 5.3% | 1.56 | 1.49 | 1.63 | |
Antiepileptics | 1,342 | 1.4% | 1,016 | 1.1% | 1.37 | 1.23 | 1.52 | |
Anti-Parkinson agents | 259 | 0.3% | 149 | 0.2% | 1.88 | 1.45 | 2.43 | |
Anti-dementia agents | 1,072 | 1.1% | 945 | 1.0% | 1.16 | 1.03 | 1.30 | |
Others | Benign prostatic hypertrophy agents | 1,387 | 1.5% | 1,095 | 1.2% | 1.31 | 1.18 | 1.45 |
Antacids | 8,287 | 8.8% | 8,057 | 8.6% | 1.03 | 0.99 | 1.07 | |
H2-receptor antagonists | 11,569 | 12.3% | 10,306 | 10.9% | 1.13 | 1.09 | 1.17 | |
Laxatives | 804 | 0.9% | 701 | 0.7% | 1.16 | 1.02 | 1.32 | |
NSAIDs/antirheumatic agents | 16,069 | 17.1% | 12,328 | 13.1% | 1.32 | 1.28 | 1.36 | |
Muscle relaxants | 10,442 | 11.1% | 6,513 | 6.9% | 1.65 | 1.59 | 1.72 | |
Corticosteroids (systemic) | 5,812 | 6.2% | 5,589 | 5.9% | 1.04 | 1.00 | 1.09 | |
Asthma/COPD agents | 3,516 | 3.7% | 3,735 | 4.0% | 0.94 | 0.89 | 1.00 | |
Cough and cold preparations | 10,691 | 11.3% | 11,923 | 12.7% | 0.89 | 0.87 | 0.92 | |
Antihistamines (systemic) | 9,861 | 10.5% | 10,786 | 11.4% | 0.91 | 0.88 | 0.94 | |