Table 3 Incidence rates and hazard ratios for mortality
Measure | Events | Person-time (years) | Crude IR (per 1,000 PY) | Adjusted Hazard Ratio (95% CI) |
|---|---|---|---|---|
Overall | 1129 | 42,887 | 26.33 | |
Anticholinergic polypharmacy | ||||
No ACH exposure | 623 | 32,133 | 19.39 | Reference |
1 ACH meds | 321 | 8680 | 36.98 | 1.42 (1.2—1.6) |
2 ACH meds | 131 | 1638 | 79.98 | 2.64 (2.1—3.3) |
3 ACH meds | 40 | 347 | 115.27 | 3.75 (2.6—5.4) |
≥ 4 ACH meds | 14 | 88 | 159.09 | 3.36 (1.8—6.4) |
Cumulative Anticholinergic Exposure | ||||
Low | 494 | 22,752 | 21.70 | Reference |
Moderate | 279 | 11,051 | 25.20 | 1.21 (1.01—1.41) |
High | 162 | 4655 | 34.80 | 1.51 (1.25—1.83) |
Very High | 194 | 4429 | 43.80 | 2.11 (1.76—2.52) |