Table 2 Incidence rates and hazard ratios for the incidence of Dementia/Alzheimer's disease
Measure | Events | Person-time (years) | Crude IR (per 1,000 PY) | Adjusted Hazard Ratio (95% CI) |
|---|---|---|---|---|
Overall | 819 | 41,437 | 19.77 | |
Anticholinergic polypharmacy | ||||
No ACH exposure | 474 | 31,249 | 15.17 | Reference |
1 ACH meds | 253 | 8290 | 30.52 | 1.64 (1.39—1.93) |
2 ACH meds | 69 | 1515 | 45.54 | 2.17 (1.67—2.83) |
3 ACH meds | 17 | 305 | 55.74 | 2.59 (1.54—4.36) |
≥ 4 ACH meds | 6 | 78 | 76.92 | 2.59 (1.06—6.32) |
Cumulative Anticholinergic Exposure | ||||
Low | 386 | 22,246 | 17.35 | Reference |
Moderate | 202 | 10,688 | 18.90 | 1.05 (0.88—1.25) |
High | 108 | 4424 | 24.41 | 1.17 (0.93—1.48) |
Very High | 123 | 4079 | 30.15 | 1.32 (1.04—1.68) |