Sleep movements and respiratory coupling as a biobehavioral metric for early Alzheimer’s disease in independently dwelling adults

Table 3 Neurocognitive Performance and Sleep Fragmentation (SF) and WASO

Neurocognitive Test		Unadjusted [p (95% CI)]	Adjusted [p (95% CI)]	Post-hoc
SF^a	^aHVLT-R Raw (total recall)	0.004 (1.37, 7.15)	0.009 (0.95, 6.36)	Tertile 2 > Tertile 3
SF^a	HVLT-R Raw (delayed recall)	0.004 (0.81, 4.02)	0.008 (0.54, 3.56)	Tertile 2 > Tertile 3
WASO^b	BVMT-R Raw (trial 1)	0.013 (0.27, 2.24)	0.014 (0.25, 2.14)	Tertile 1 > Tertile 3
WASO^b	HVLT-R Raw (total recall)	0.044 (0.09, 6.01)	0.057 (-0.09, 5.66)	Tertile 1 > Tertile 3

Multivariable regression of significant actigraphy predictors of neurocognitive performance adjusted for age, current depressive symptoms, BMI, and education years. SF/HVLT-R (total recall): F(7,82) = 193.8, p < .001, η2 = .945; SF/HVLT-R (delayed recall): F(7,82) = 70.4, p < .001, η2 = .862. WASO/BVMTR (trial 1): F(7, 82) = 184.3., p < .001, η2 = .942; WASO/HVLTR-R(total recall): F(7,82) = 34.6, p < .001, η2 = .862
^aTertile 1: n = 29; mean = 21.33 ± 3.51 counts, 12.83 to 25.89; Tertile 2: n = 29; mean = 32.59 ± 3.63 counts, 26.15 to 38.96; Tertile 3: n = 31; mean = 51.63 ± 11.72 counts, 39.40 to 93.13
^bTertile 1: n = 29; mean = 31.65 ± 7.77 min, 19.29 to 42.80; Tertile 2: n = 29; mean = 51.38 ± 5.17 min, 42.85 to 60.29; Tertile 3: n = 31; mean = 83.63 ± 25.49 min, 61.15 to 178.43

ISSN: 1471-2318