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Table 3 Pneumonia risk factors in both cohorts

From: Risk factors of pneumonia in persons with and without Alzheimer’s disease: a matched cohort study

Variable

Unadjusted HR (95% CI), Cox regression

Adjusted HR (95% CI), Cox regression*

Adjusted HR (95%CI) in competing risk model*

AD

1.82 (1.78–1.87)

1.76 (1.71–1.80)

1.54 (1.51–1.58)

Age**

1.06 (1.06–1.06)

1.06 (1.06–1.07)

1.03 (1.03–1.04)

Men**

1.81 (1.77–1.85)

2.09 (2.04–2.14)

1.88 (1.84–1.93)

Socioeconomic position, n (%)**

 Managerial/professional

1.00 (reference)

1.00 (reference)

1.00 (reference)

 Office

0.93 (0.88–0.98)

1.08 (1.02–1.13)

1.07 (1.04–1.11)

 Farming/forestry

1.51 (1.45–1.56)

1.24 (1.20–1.29)

0.91 (0.86–0.95)

 Sales/industrial/cleaning

1.29 (1.25–1.34)

1.19 (1.15–1.23)

0.85 (0.82–0.88)

 Other

1.19 (1.14–1.25)

1.06 (1.01–1.18)

0.99 (0.94–1.03)

Comorbidities

 Asthma/COPD**

1.81 (1.74–1.87)

1.59 (1.54–1.65)

1.54 (1.48–1.59)

 Rheumatoid Arthritis**

1.46 (1.37–1.55)

1.37 (1.29–1.46)

1.30 (1.22–1.39)

 Cardiovascular disease**

1.41 (1.37–1.44)

1.15 (1.12–1.18)

1.06 (1.03–1.09)

 Diabetes**

1.40 (1.35–1.44)

1.21 (1.17–1.25)

1.09 (1.05–1.13)

 Stroke**

1.72 (1.66–1.78)

1.30 (1.26–1.35)

1.19 (1.14–1.23)

 Liver or kidney disease**

1.68 (1.57–1.81)

1.21 (1.12–1.30)

0.99 (0.92–1.07)

 Previous hospital-treated pneumonia**

3.25 (3.14–3.36)

2.25 (2.18–2.33)

1.92 (1.85–1.99)

Drug use

 Benzodiazepine or related drug**

1.32 (1.29–1.36)

1.09 (1.06–1.12)

1.10 (1.07–1.13)

 Antidepressant**

1.33 (1.30–1.37)

1.09 (1.06–1.13)

1.08 (1.04–1.11)

 Antipsychotic**

1.68 (1.62–1.75)

1.32 (1.27–1.38)

1.18 (1.13–1.23)

 Antiepileptic**

1.69 (1.62–1.77)

1.39 (1.32–1.45)

1.36 (1.29–1.42)

 Opioid**

1.44 (1.38–1.50)

1.16 (1.11–1.21)

1.08 (1.04–1.13)

 Biological products

1.18 (1.08–1.29)

1.10 (1.01–1.21)

1.04 (0.95–1.14)

 Oral glucocorticoid

2.10 (1.65–2.69)

1.68 (1.32–2.15)

1.42 (1.09–1.85)

 Proton pump inhibitor**

1.37 (1.34–1.41)

1.15 (1.12–1.19)

1.10 (1.07–1.13)

  1. *adjusted for age, gender, comorbidities, and drug use
  2. **P for AD-risk factor interaction < 0.05