From: Risk factors of pneumonia in persons with and without Alzheimer’s disease: a matched cohort study
Variable | Unadjusted HR (95% CI), Cox regression | Adjusted HR (95% CI), Cox regression* | Adjusted HR (95%CI) in competing risk model* |
---|---|---|---|
AD | 1.82 (1.78–1.87) | 1.76 (1.71–1.80) | 1.54 (1.51–1.58) |
Age** | 1.06 (1.06–1.06) | 1.06 (1.06–1.07) | 1.03 (1.03–1.04) |
Men** | 1.81 (1.77–1.85) | 2.09 (2.04–2.14) | 1.88 (1.84–1.93) |
Socioeconomic position, n (%)** | |||
Managerial/professional | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
Office | 0.93 (0.88–0.98) | 1.08 (1.02–1.13) | 1.07 (1.04–1.11) |
Farming/forestry | 1.51 (1.45–1.56) | 1.24 (1.20–1.29) | 0.91 (0.86–0.95) |
Sales/industrial/cleaning | 1.29 (1.25–1.34) | 1.19 (1.15–1.23) | 0.85 (0.82–0.88) |
Other | 1.19 (1.14–1.25) | 1.06 (1.01–1.18) | 0.99 (0.94–1.03) |
Comorbidities | |||
Asthma/COPD** | 1.81 (1.74–1.87) | 1.59 (1.54–1.65) | 1.54 (1.48–1.59) |
Rheumatoid Arthritis** | 1.46 (1.37–1.55) | 1.37 (1.29–1.46) | 1.30 (1.22–1.39) |
Cardiovascular disease** | 1.41 (1.37–1.44) | 1.15 (1.12–1.18) | 1.06 (1.03–1.09) |
Diabetes** | 1.40 (1.35–1.44) | 1.21 (1.17–1.25) | 1.09 (1.05–1.13) |
Stroke** | 1.72 (1.66–1.78) | 1.30 (1.26–1.35) | 1.19 (1.14–1.23) |
Liver or kidney disease** | 1.68 (1.57–1.81) | 1.21 (1.12–1.30) | 0.99 (0.92–1.07) |
Previous hospital-treated pneumonia** | 3.25 (3.14–3.36) | 2.25 (2.18–2.33) | 1.92 (1.85–1.99) |
Drug use | |||
Benzodiazepine or related drug** | 1.32 (1.29–1.36) | 1.09 (1.06–1.12) | 1.10 (1.07–1.13) |
Antidepressant** | 1.33 (1.30–1.37) | 1.09 (1.06–1.13) | 1.08 (1.04–1.11) |
Antipsychotic** | 1.68 (1.62–1.75) | 1.32 (1.27–1.38) | 1.18 (1.13–1.23) |
Antiepileptic** | 1.69 (1.62–1.77) | 1.39 (1.32–1.45) | 1.36 (1.29–1.42) |
Opioid** | 1.44 (1.38–1.50) | 1.16 (1.11–1.21) | 1.08 (1.04–1.13) |
Biological products | 1.18 (1.08–1.29) | 1.10 (1.01–1.21) | 1.04 (0.95–1.14) |
Oral glucocorticoid | 2.10 (1.65–2.69) | 1.68 (1.32–2.15) | 1.42 (1.09–1.85) |
Proton pump inhibitor** | 1.37 (1.34–1.41) | 1.15 (1.12–1.19) | 1.10 (1.07–1.13) |