The role of medication adherence in the association between depressive symptoms and quality of life in older adults with type 2 diabetes mellitus

Table 3 Interaction effect between medication adherence and depressive symptoms on QOL in older adults with T2DM

Variables	Model 1		Model 2		Model 3
Variables	β (95%CI)	P	β (95%CI)	P	β (95%CI)	P
MMAS-8*Depression
Level 1	Reference
Level 2	3.43 (0.95, 5.92)	0.007	3.58 (1.07, 6.09)	0.005	3.95 (1.42, 6.48)	0.002
Level 3	6.98 (4.34, 9.61)	< 0.001	6.86 (4.22, 9.50)	< 0.001	6.89 (4.21, 9.57)	< 0.001
Level 4	8.36 (6.09, 10.63)	< 0.001	8.47 (6.20, 10.73)	< 0.001	8.57 (6.24, 10.91)	< 0.001
MMAS-8*Depression
MMAS-8	1.39 (-0.62, 3.78)	0.175	1.60 (-0.46, 3.67)	0.127	1.68 (-0.30, 3.66)	0.095
Depression	-9.03 (-14.62, -3.44)	0.002	-8.84 (-14.43, -3.25)	0.002	-9.15 (-14.77, -3.54)	0.002
MMAS-8*Depression	2.05 (-1.15, 5.25)	0.208	1.98 (-1.22, 5.17)	0.224	2.26 (-0.93, 5.46)	0.165

Level 1: MMAS-8 < 6 & Depression, Level 2: MMAS-8 ≥ 6 & Depression, Level 3: MMAS-8 < 6 & Non-depression, and Level 4: MMAS-8 ≥ 6 & Non-depression
Model 1: Unadjusted univariate linear regression model
Model 2: Multivariable linear regression adjusted for age and gender
Model 3: Multivariable linear regression adjusted for age, gender, BMI, LDL and 2hPG
QOL Quality of life, T2DM Type 2 diabetes mellitus, MMAS Morisky medication adherence scale

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