The role of medication adherence in the association between depressive symptoms and quality of life in older adults with type 2 diabetes mellitus

Table 2 Associations of depressive symptoms with medication compliance or QOL in older adults with T2DM

Outcomes	Model 1		Model 2		Model 3
Outcomes	β (95%CI)	P	β (95%CI)	P	β (95%CI)	P
MMAS-8	-0.58 (-1.00, -0.16)	0.007	-0.64 (-1.04, -0.23)	0.002	-0.67 (-1.10,-0.24)	0.002
M1	-0.17 (-0.28, -0.05)	0.004	-0.18 (-0.30, -0.07)	0.002	-0.20 (-0.32, -0.09)	< 0.001
M2	-0.11 (-0.20, -0.01)	0.025	-0.11 (-0.21, -0.02)	0.018	-0.12 (-0.22, -0.02)	0.015
M3	-0.07 (-0.17, 0.03)	0.185	-0.07 (-0.18, 0.03)	0.158	-0.08 (-0.18, 0.03)	0.150
M4	-0.10 (-0.21, 0.01)	0.060	-0.12 (-0.22, -0.01)	0.037	-0.12 (-0.23, -0.01)	0.038
M5	-0.02 (-0.10, 0.07)	0.654	-0.02 (-0.11, 0.06)	0.615	-0.01 (-0.09, 0.09)	0.971
M6	-0.01 (-0.09, 0.07)	0.804	-0.01 (-0.10, 0.07)	0.739	-0.01 (-0.10, 0.08)	0.817
M7	-0.06 (-0.16, 0.04)	0.246	-0.08 (-0.18, 0.03)	0.146	-0.09 (-0.19, 0.02)	0.106
M8	-0.04 (-0.08, 0.01)	0.116	-0.04 (-0.09, 0.01)	0.087	-0.05 (-0.10, 0.01)	0.051
QOL	-6.13 (-7.64, -4.62)	< 0.001	-6.11 (-7.63, -4.60)	< 0.001	-5.99 (-7.56, -4.42)	< 0.001
Q1	-0.41 (-0.60, -0.21)	< 0.001	-0.41 (-0.61, -0.22)	< 0.001	-0.36 (-0.57, -0.16)	< 0.001
Q2	-0.36 (-0.59, -0.13)	0.002	-0.37 (-0.60, -0.14)	0.002	-0.37 (-0.61, -0.13)	0.003
Q3	-2.19 (-2.71, -1.67)	< 0.001	-2.15 (-2.66, -1.64)	< 0.001	-2.09 (-2.62, -1.56)	< 0.001
Q4	-1.70 (-2.18, -1.22)	< 0.001	-1.67 (-2.15, -1.19)	< 0.001	-1.64 (-2.13, -1.14)	< 0.001
Q5	-1.18 (-1.65, -0.70)	< 0.001	-1.22 (-1.69, -0.74)	< 0.001	-1.25 (-1.74, -0.76)	< 0.001
Q6	-0.29 (-0.40, -0.18)	< 0.001	-0.29 (-0.41, -0.18)	< 0.001	-0.28 (-0.40, -0.16)	< 0.001

Model 1: Unadjusted univariate linear regression model
Model 2: Multivariable linear regression adjusted for age and gender
Model 3: Multivariable linear regression adjusted for age, gender, BMI, LDL and 2hPG
QOL Quality of life, T2DM Type 2 diabetes mellitus, MMAS Morisky medication adherence scale

ISSN: 1471-2318