Table 2 Predictive values of cognitive function in amyloid accumulation
From: Computer-based cognitive tests and cerebral pathology among Japanese older adults
Memory | TMT-A | TMT-B | DSST | MMSE | |||||
|---|---|---|---|---|---|---|---|---|---|
> 1.0SD below | > 1.5SD below | > 1.0SD below | > 1.5SD below | > 1.0SD below | > 1.5SD below | > 1.0SD below | > 1.5SD below | Cutoff value | |
Accuracy | 0.73 (0.64–0.81) | 0.82 (0.74–0.89) | 0.75 (0.66–0.83) | 0.79 (0.71–0.87) | 0.74 (0.65–0.82) | 0.80 (0.72–0.87) | 0.79 (0.71–0.87) | 0.83 (0.75–0.90) | 0.80 (0.72–0.87) |
Sensitivity | 0.39 (0.20–0.61) | 0.28 (0.12–0.51) | 0.06 (0–0.28) | 0.06 (0–0.28) | 0.17 (0.05–0.40) | 0.17 (0.05–0.40) | 0.33 (0.16–0.56) | 0.33 (0.16–0.56) | 0.17 (0.05–0.40) |
Specificity | 0.80 (0.70–0.87) | 0.93 (0.85–0.97) | 0.89 (0.81–0.94) | 0.94 (0.87–0.98) | 0.86 (0.77–0.92) | 0.93 (0.85–0.97) | 0.88 (0.79–0.94) | 0.93 (0.85–0.97) | 0.93 (0.85–0.97) |
Positive predictive value | 0.29 (0.11–0.47) | 0.45 (0.16–0.75) | 0.10 (0–0.29) | 0.17 (0–0.46) | 0.20 (0–0.40) | 0.33 (0.03–0.64) | 0.38 (0.14–0.61) | 0.50 (0.22–0.78) | 0.33 (0.03–0.64) |
Negative predictive value | 0.86 (0.78–0.94) | 0.86 (0.79–0.93) | 0.82 (0.74–0.90) | 0.82 (0.75–0.90) | 0.83 (0.75–0.91) | 0.84 (0.77–0.91) | 0.86 (0.79–0.93) | 0.87 (0.80–0.94) | 0.84 (0.77–0.91) |
Relative risk | 2.09 (0.94–4.67) | 3.22 (1.48–7.01) | 0.55 (0.12–2.55) | 0.95 (0.22–4.12) | 1.17 (0.42–3.28) | 2.09 (0.81–5.40) | 2.72 (1.24–5.98) | 3.79 (1.81–7.95) | 2.09 (0.81–5.40) |
Number needed to screen for Aβ + | 3.45 | 2.22 | 5.26 | 5.88 | 5.00 | 3.03 | 2.63 | 2.00 | 3.03 |