Lower serum FT3 within the reference range is associated with mortality for older adults over 80 years of age with sarcopenia

Table 3 Cox proportional hazard regression analysis of mortality

Variables	Univariate		Multivariate (Model 1)		Multivariate (Model 2)
Variables	HR (95%CI)	P	HR (95%CI)	P	HR (95%CI)	P
Age	1.07(1.03–1.13)	0.002	1.06(1.01–1.12)	0.011	1.03(0.98–1.09)	0.298
Sex	0.43(0.23–0.77)	0.005	0.41(0.22–0.79)	0.008	0.42(0.19–0.95)	0.036
Smoking	0.67(0.42–1.07)	0.190
Drinking	1.31(0.41–4.15)	0.645
CI	0.65(0.43–0.99)	0.043	1.16(0.72–1.87)	0.532	0.97(0.88–1.08)	0.557
COPD	1.75(1.14–2.68)	0.010	1.29(0.79–2.11)	0.294	1.39(0.78–2.45)	0.263
CHD	1.18(0.75–1.85)	0.479
Diabetes	1.01(0.65–1.57)	0.969
Hypertension	1.04(0.56–1.91)	0.907
dyslipidemia	1.12(0.67–1.86)	0.672
Neoplasms	0.59(0.37–0.96)	0.032	2.41(1.45–4.01)	0.001	1.77(0.94–3.32)	0.080
BMI	0.91(0.83–0.99)	0.025			0.97(0.88–1.07)	0.557
CC	0.81(0.76–0.87)	< 0.001			0.86(0.76–0.97)	0.015
HGS	0.97(0.94–1.01)	0.111
FT3	0.43(0.31–0.59)	< 0.0001	0.65(0.49–0.87)	0.004	0.63(0.41–0.96)	0.031
FT4	0.95(0.88–1.03)	0.220
TSH	1.01(1.00–1.01)	0.901

Age, sex, CI, COPD, Neoplasms, FT3 were included in the multivariate model 1. Age, sex, CI, COPD, Neoplasms, BMI, CC, FT3 were included in the multivariate model 2
Abbreviations: CI Cerebral infarction, COPD Chronic obstructive pulmonary disease, CHD Coronary heart disease, BMI Body mass index, CC Calf circumference; HGS: Handgrip strength, FT3 Free Triiodothyronine, FT4 Free Thyroxine, TSH Thyroid stimulating hormone

ISSN: 1471-2318