Table 1 Initial characteristics of patients included in each group of the randomised PROPAGE study (N = 107).
| Ā | Ā | Control group (nā=ā57) | PCT group (nā=ā50) | p value |
|---|---|---|---|---|
Gender, N (%) | Female | 29 (50.9%) | 25 (50.0%) | 0.93 |
| Ā | Male | 28 (49.1%) | 25 (50.0%) | Ā |
Age (years), mean (SD) | Ā | 87.6 (5.0) | 88.0 (5.1) | 0.66 |
Residence, N (%) | Own home | 44 (77.2%) | 39 (79.6%) | 0.77 |
| Ā | Nursing home | 13 (22.8%) | 10 (20.4%) | Ā |
Smoking status, N (%) | Yes | 2 (3.6%) | 2 (4.1%) | >ā0.99* |
| Ā | No | 45 (81.8%) | 40 (81.6%) | Ā |
| Ā | Former smoker | 8 (14.5%) | 7 (14.3%) | Ā |
MNA at inclusion, N (%) | Normal | 1 (4.0%) | - | 0.84* |
| Ā | Risk of malnutrition | 11 (44.0%) | 8 (53.3%) | Ā |
| Ā | Poor nutritional status | 13 (52.0%) | 7 (46.7%) | Ā |
ADLs score on Day āā15, N (%) | 0-1.5 | 3 (8.3%) | 3 (8.1%) | >ā0.99* |
| Ā | 2-3.5 | 8 (22.2%) | 9 (24.3%) | Ā |
| Ā | 4ā6 | 25 (69.4%) | 25 (67.6%) | Ā |
ADLs score on Day 0, N (%) | 0-1.5 | 7 (20.6%) | 6 (17.6%) | 0.65* |
| Ā | 2-3.5 | 11 (35.3%) | 8 (23.5%) | Ā |
| Ā | 4ā6 | 16 (47.1%) | 20 (58.8%) | Ā |
IADL on Day āā15, N (%) | 0ā2 | 18 (50.0%) | 13 (36.1%) | 0.39* |
| Ā | 3ā5 | 6 (16.7%) | 5 (13.9%) | Ā |
| Ā | 6ā8 | 12 (33.3%) | 18 (50.0%) | Ā |
Mental status, N (%) | Impaired | 17 (31.5%) | 15 (31.2%) | 0.98 |
SBP (mmHg), mean (SD) | Ā | 130.7 (26.3) | 130.8 (22.1) | 0.98 |
DBP (mmHg), mean (SD) | Ā | 69.7 (14.3) | 69.6 (13.0) | 0.96 |
Heart rate (bpm), mean (SD) | Ā | 83.5 (18.1) | 80.3 (17.2) | 0.35 |
Respiratory rate (breath/min), mean (SD) | Ā | 22.6 (5.5) | 25.0 (10.8) | 0.37 |
PAO2 (mmHg), mean (SD) | Ā | 66.6 (23.4) | 74.9 (31.4) | 0.31 |
Leukocytes (/Āµl), mean (SD) | Ā | 9917 (5577) | 10,971 (13,020) | 0.62 |
Eosinophils (%) | Ā | 1.4 (2.2) | 1.8 (2.7) | 0.47 |
PCT (ng/ml), mean (SD) | Ā | 4.84 (12.73) | 2.6 (6.70) | 0.25 |
Cough, N (%) | Ā | 36 (65.4%) | 26 (55.3%) | 0.30 |
Bronchial congestion, N (%) | Ā | 31 (57.4%) | 21 (42.9%) | 0.14 |
Chest pain, N (%) | Ā | 2 (3.8%) | 3 (6.1%) | 0.67* |
Purulent sputum, N (%) | Ā | 13 (25.0%) | 12 (25.0%) | >ā0.99 |
History of pneumonia | Ā | 48 (87.3%) | 44 (88.0%) | >ā0.99* |
PSI (lowest risk class at least), N (%) | III | 12 (21.0%) | 8 (16.0%) | 0.07 |
| Ā | IV | 28(49.1%) | 35 (70.0%) | Ā |
| Ā | V | 17 (29.8%) | 7 (14.0%) | Ā |
CURB 65 (lowest risk class at least), N (%) | 1 | 8 (14.0%) | 6 (12.0%) | 0.83* |
| Ā | 2 | 24 (42.1%) | 23 (46.0%) | Ā |
| Ā | 3 | 25 (43.9%) | 20 (40.0%) | Ā |
| Ā | 4 | - | 1 (2.0%) | Ā |
APACHE II, mean (SD) | Ā | 10.8 (3.9) | 10.2 (3.6) | 0.47 |