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Table 1 Frailty by quartiles at age 75 and FRAX score, fractures and falls

From: Can frailty in conjunction with FRAX identify additional women at risk of fracture - a longitudinal cohort study of community dwelling older women

All variables at 75y

Low Frailty Q1 (<=0.02)

Frailty Q2 (0.02–0.12)

Frailty Q3 (0.13–0.27)

Highly Frail Q4 (0.28+)

No

p# Overall

p Q1 vs Q4

 

n = 261

n = 254

n = 262

n = 267

   
 

Mean

range

Mean

range

Mean

range

Mean

range

   

Frailty Index

0.002

(0.00–0.02)

0.08

(0.03–0.12)

0.18

(0.13–0.27)

0.41

(0.28–0.88)

 

 FRAXHIP no BMD

13.4

(5.1–61.0)

13.3

(4.3–57.0)

14.1

(4.2–53.0)

14.4

(3.9–58.0)

1023

0.362

0.172

 FRAXMOF no BMD

26.3

(14.0–68.0)

26.7

(13.0–68.0)

27.7

(12.0–64.0)

28.1

(12.0–69.0)

1023

0.151

0.051

Fractures

No

(%)

No

(%)

No

(%)

No

(%)

   

 Prior any fx (20-75y)

97

(21.2)

104

(22.8)

122

(26.7)

134

(29.3)

457

0.011

0.002

 Prior any fx (50-75y)

74

(19.3)

91

(23.8)

99

(25.8)

119

(31.1)

383

0.001

< 0.001

 Prior MOF (50-75y)

55

(23.9)

53

(22.1)

65

(27.1)

67

(27.9)

240

0.505

0.242

Falls in the last year 1

No

(%)

No

(%)

No

(%)

No

(%)

   

 1 or more falls reported

31

(11.9)

43

(16.5)

78

(30.0)

108

(41.5)

260

< 0.001

< 0.001

 3 or more falls reported

2

(2.9)

5

(7.2)

21

(30.4)

41

(59.4)

69

< 0.001

< 0.001

Bone mineral density2

Median

IQR

Median

IQR

Median

IQR

Median

IQR

   

 Femoral neck T-score

−1.78

(1.46)

−1.75

(1.60)

−1.98

(1.48)

−1.92

(1.56)

947

0.370

0.215

 Femoral neck BMD (g/cm2)

0.766

(0.175)

0.751

(0.191)

0.742

(0.177)

0.749

(0.187)

947

0.370

0.215

  1. Reported values are means, unless otherwise stated. # p-values calculated by ANOVA, Kruskal Wallace or Chi-square as appropriate
  2. 1Bartosch PS, Kristensson J, McGuigan FE, Akesson KE. Frailty and prediction of recurrent falls over 10 years in a community cohort of 75-year-old women. Aging Clin Exp Res. 2020;32 (11):2241–50
  3. 2Bartosch P, Malmgren L, Kristensson J, McGuigan FE, Akesson KE. In community-dwelling women frailty is associated with imminent risk of osteoporotic fractures. Osteoporos Int. 2021;32 (9):1735–44