Table 1 Demographic and selected clinical characteristics

Age (yrs)

82.45 (7.11)

83.18 (7.12)

81.07 (6.91)

0.026

-0.299

-0.565- -0.034

BMI (Kg/m2)

25.77 (6.06)

25.53 (6.61)

26.32 (4.51)

ns

-

-

Glucose (mg/dL)

99.16 (29.93)

99.29 (31.95)

98.91 (25.91)

ns

-

-

HbA1C (%)

6.08 (1.56)

6.15 (1.63)

5.95 (1.41)

ns

-

-

Total protein (g/dL)

6.58 (0.59)

6.57 (0.59)

6.59 (0.60)

ns

Albumin (g/dL)

54.61 (8.03)

53.44 (7.67)

56.62 (8.29)

0.010

0.403

0.137–0.670

Total cholesterol (mg/dL)

159.16 (40.44)

163.86 (40.42)

150.50 (39.32)

0.024

-0.334

-0.599- -0.068

LDL cholesterol (mg/dL)

88.75 (32.79)

90.76 (32.53)

85.04 (33.17)

ns

-

-

HDL cholesterol (mg/dL)

49.69 (14.17)

51.39 (14.62)

46.56 (12.81)

0.021

-0.344

-0.610- -0.079

Triglycerides (mg/dL)

116.74

122.65 (71.97)

105.84 (44.21)

ns

-

-

Creatinine (mg/dL)

1.12 (0.43)

1.05 (0.43)

1.24 (0.40)

 < 0.0001

0.452

0.185–0.720

Total bilirubin (mg/dL)

0.70 (0.36)

0.67 (0.34)

0.75 (0.38)

ns

-

-

Uric acid (mg/dL)

4.64 (1.39)

4.58 (1.40)

4.78 (1.38)

ns

-

-

Ferritin (ng/mL)

142.50 (130.75)

126.07 (126.43)

170.34 (134.08)

0.004

0.343

0.077–0.609

C-Reactive Protein (mg/L)

14.63 (20.90)

15.30 (22.60)

13.17 (17.07)

ns

-

-

RBC (× 10¹²/L)

4.26 (0.65)

4.20 (0.60)

4.37 (0.73)

0.017

0.263

0.003–0.528

WBC (× 10⁹/L)

6.74 (2.09)

6.91 (2.28)

6.41 (1.64)

ns

-

-

Lymphocytes %

24.64 (10.58)

26.07 (10.67)

22.06 (9.99)

0.012

-0.384

-0.650- -0.118

Neutrophils %

56.57 (16.05)

56.88 (14.48)

55.99 (18.63)

ns

-

-

Monocytes %

10.31 (5.18)

10.22 (4.88)

10.48 (5.70)

ns

-

-

Basophils %

0.83 (0.53)

0.83 (0.53)

0.81 (0.52)

ns

-

-

Eosinophils %

2.55 (2.13)

2.50 (2.13)

2.65 (2.15)

ns

-

-

Platelets (× 10⁹/L)

244.48 (107.28)

262.19 (117.33)

212.73 (77.43)

 < 0.0001

-0.469

-0.737—-0.202

HGS (Kg)

17.54 (10.49)

12.53 (5.98)

24.91 (11.36)

 < 0.0001

1.504

1.208—1.80

GS Gait Speed (m/s)

0.64 (0.28)

0.55 (0.22)

0.78(0.32)

0.001

0.889

0.613—1.165

MMSE

18.01 (5.64)

17.52 (5.87)

18.91 (5.12)

ns

-

-

ADL dependence (> 1)

65.5%

71.8%

53.2%

0.008

0.351

-

CIRS-TS

17.71 (12.57)

17.86 (12.65)

17.38 (12.47)

ns

-

-

CIRS- CI

2.54 (2.90)

2.62 (3.01)

2.37 (2.81)

ns

-

-

Mir-181a (log 2^{− ΔCt})

-0.28 (1.18)

-0.26 (1.22)

-0.30 (1.09)

ns

-

-