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Table 2 Top 5 Commonly Investigated TOMM40 SNPs From Studies and Their Association with Age-Related Health Factors and Longevity

From: TOMM40 genetic variants associated with healthy aging and longevity: a systematic review

Common TOMM40 SNPs

Times Identified

Associated Age-related Health Factor and/or Longevity

rs2075650

12

BMI [33, 38]; Cognitive Function [31, 49]; Longevity [7, 10, 29, 30, 34, 40, 41, 45];

Cognitive Functiona [32]; Altered Inflammatory Network [28]; Vulnerability to Vascular Risk Factors [36]

rs10524523

7

Brain Integrity [39]; Cognitive Function [37, 42, 44, 46, 48]; Longevity [47]

Brain Integritya [43]

rs157582

4

Longevity [29,30,31, 41]

rs71352238

3

Longevity [29,30,31]

rs8106922

2

Longevity [30, 41]

  1. BMI Body Mass Index
  2. aInvestigated, but no direct association found between the SNPs and the health factor