Associations of multiple chronic disease and depressive symptoms with incident stroke among Chinese middle-aged and elderly adults: a nationwide population-based cohort study

Table 4 Sensitivity analyses of the associations between multiple chronic disease status and incident stroke

Type of chronic disease^a	Incident stroke (case, No.)	Incidence rate, per 1000 person-years	Model 1		Model 2		Model 3
Type of chronic disease^a	Incident stroke (case, No.)	Incidence rate, per 1000 person-years	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
Hypertension
No	174	4.90	1.00 (reference)		1.00 (reference)		1.00 (reference)
Yes	235	12.20	2.232 (1.826–2.728)	< 0.001	1.931 (1.547–2.411)	< 0.001	1.786 (1.384–2.306)	< 0.001
Dyslipidemia
No	246	6.16	1.00 (reference)		1.00 (reference)		1.00 (reference)
Yes	163	11.00	1.508 (1.228–1.852)	< 0.001	1.453 (1.162–1.818)	0.001	1.381 (1.003–1.901)	0.048
Heart disease
No	336	6.88	1.00 (reference)		1.00 (reference)		1.00 (reference)
Yes	72	12.50	1.437 (1.107–1.864)	0.006	1.320 (0.988–1.764)	0.060	1.250 (0.896–1.744)	0.189
Diabetic status
Others	155	6.41	1.00 (reference)		1.00 (reference)		1.00 (reference)
Prediabetes	207	8.17	0.915 (0.655–1.279)	0.603	1.030 (0.714–1.487)	0.874	1.046 (0.588–1.863)	0.877
Diabetes	47	8.98	1.024 (0.744–1.409)	0.883	1.146 (0.808–1.625)	0.446	1.176 (0.717–1.930)	0.520
Chronic kidney disease
No	376	7.34	1.00 (reference)		1.00 (reference)		1.00 (reference)
Yes	33	9.88	1.251 (0.873–1.791)	0.222	1.243 (0.840–1.838)	0.277	1.353 (0.880–2.079)	0.168

Abbreviation: No. Number, HR Hazard ratio, CI Confidence interval, NA Not applicable
^a Incorporating all the four types of chronic disease in the Cox proportional hazards models
Model 1: Unadjusted model
Model 2: Adjusting for gender, age, marital status, education level, ever smoking, last year drinking, residence, body mass index, and depressive symptoms at baseline
Model 3: Adjusting for the variables in Model 2 plus clinical variables, including fasting blood glucose, triglycerides, creatine, total Cholesterol, HDL cholesterol, LDL cholesterol, High sensitivity C-reactive protein, hemoglobin, uric acid, and Cystatin C

ISSN: 1471-2318