| Incident stroke (case, No.) | Incidence rate, per 1000 person-years | Model 1 | Model 2 | Model 3 | |||
---|---|---|---|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |||
MCD a | ||||||||
  0 | 90 | 4.00 | 1.00 (reference) |  | 1.00 (reference) |  | 1.00 (reference) |  |
  1 | 150 | 7.71 | 1.922 (1.480–2.497) |  < 0.001 | 1.607 (1.213–2.130) | 0.001 | 1.562 (1.124–2.170) | 0.008 |
  ≥ 2 | 168 | 13.47 | 3.336 (2.582–4.309) |  < 0.001 | 2.578 (1.946–3.415) |  < 0.001 | 2.436 (1.702–3.487) |  < 0.001 |
Depressive symptoms | ||||||||
  No | 294 | 6.97 | 1.00 (reference) |  | NA |  | NA |  |
  Yes | 115 | 9.16 | 1.313 (1.058 ~ 1.629) | 0.013 | NA |  | NA |  |
Combined effects | ||||||||
  MCD(0)-not having depressive symptoms | 67 | 3.75 | 1.00 (reference) |  | 1.00 (reference) |  | 1.00 (reference) |  |
  MCD(0)-having depressive symptoms | 23 | 4.97 | 1.326 (0.825–2.129) | 0.243 | 1.469 (0.897–2.406) | 0.127 | 1.662 (0.953–2.897) | 0.073 |
  MCD(1)-not having depressive symptoms | 113 | 7.52 | 2.002 (1.480–2.708) |  < 0.001 | 1.756 (1.268–2.432) | 0.001 | 1.738 (1.182–2.555) | 0.005 |
  MCD(1)-having depressive symptoms | 37 | 8.35 | 2.219 (1.485–3.315) |  < 0.001 | 1.795 (1.143–2.817) | 0.011 | 1.943 (1.166–3.238) | 0.011 |
  MCD(≥ 2)-not having depressive symptoms | 113 | 12.45 | 3.290 (2.432–4.451) |  < 0.001 | 2.730 (1.963–3.796) |  < 0.001 | 2.793 (1.842–4.234) |  < 0.001 |
  MCD(≥ 2)-having depressive symptoms | 55 | 16.23 | 4.276 (2.993–6.109) |  < 0.001 | 3.262 (2.183–4.876) |  < 0.001 | 3.000 (1.846–4.877) |  < 0.001 |
Multiplicative interaction | ||||||||
  Multiple chronic disease × Depressive symptoms | NA | NA | NA | 0.941 | NA | 0.640 | NA | 0.258 |