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Table 4 Genotyping

From: A clinicopathological study of selected cognitive impairment cases in Lothian, Scotland: enhanced CJD surveillance in the 65 + population group

 

N

%

Genotyping (PRNP-Codon 129)

Study consented

25

83%

Of whom tested

25

100%

  MM

8

32%

  MV

13

52%

  VV

4

16%

Duration of illness (from the onset of symptoms to censor date/death)

  MM

Mean = 8.3 years (1.1 – 16.6 years, std dev 5.5)

  MV

Mean = 10.4 years (4.1 – 17.4 years, std dev 4.6)

  VV

Mean = 11.3 years (6.6 – 16.6 years, std dev 4.7)

Age at onset of symptoms

  MM

Mean = 64 years (56 – 79 years, std dev 7.4)

  MV

Mean = 65 years (53 – 78 years, std dev 7.8)

  VV

Mean = 63 years (56 – 69 years, std dev 5.4)

Gender

  MM

Male = 5 (63%), Female = 3 (37%)

  MV

Male = 8 (62%), Female = 5 (38%)

  VV

Male = 2 (50%), Female = 2 (50%)

  Not known

Male = 4 (80%), Female = 1 (20%)

  1. Note: Std dev is standard deviation