Table 3 Brain MRI Investigation Results
Case | Date of onseta | MRI date | Period ~ (days) | Summary of abnormality |
|---|---|---|---|---|
ID 1 | 01/12/2012 | 07/08/2013 | 249 | Generalised cerebral atrophy, exaggerated in occipital lobes |
ID 2 | 15/07/2013 | 15/09/2015 | 792 | Moderate global cerebral atrophy, accelerated for age. Minor small vessel change with no focus on ischaemic change |
ID 3 | 15/07/2009 | 31/10/2013 | 1569 | Moderate diffuse prominence of the ventriculosulcal system, slightly more prominent in the frontal and parietal lobes bilaterally and slightly advanced for age. Patchy hyper intense FLAIR signal present throughout the cerebral deep white matter. Global cerebral atrophy. More focal atrophy left temporal lobe and peri-insular cortex |
ID 4 | 15/07/2011 | 28/04/2014 | 1018 | Marked diffuse prominence of the ventriculosulcal system, advanced for stated age. More prominent in temporal and parietal lobes bilaterally |
ID 5 | 15/07/2004 | 19/06/2014 | 3626 | Generalised cerebral atrophy, probably slightly advanced for age |
ID 6 | 15/07/2011 | 21/09/2016 | 1895 | Mild bilateral temporal lobe atrophy, worse on the left. No features of prion disease |
ID 7 | 20/10/2015 | 12/08/2016 | 297 | Moderate microvascular ischaemia probably more recent punctate cortical infarction in the high right parietal lobe |
ID 8 | 15/07/2010 | 06/10/2016 | 2275 | Subtle biparietal volume loss in keeping with Alzheimer's type dementia. No features of prion disease |
ID 9 | 15/10/2013 | 13/03/2014 | 149 | Cerebral atrophy, advanced for age |
ID 10 | 15/07/2003 | 06/04/2009 | 2092 | Mild degree of generalised atrophy for age but otherwise examination unremarkable |
ID 11 | 01/12/2015 | 17/06/2017 | 564 | No imaging features of prion disease. Global atrophy, with more focal atrophy in perisylvian cortex bilaterally and left medial temporal lobe structures. Enlarged lateral and third ventricles are most likely secondary to atrophy |
ID 12 | 15/07/2014 | 16/12/2016 | 885 | Marked medial temporal lobe atrophy supporting diagnosis of AD. Non-specific white matter changes most likely secondary to small vessel disease |
ID 13 | 15/07/2013 | 10/05/2017 | 1395 | No MR features of CJD. Advanced global atrophy with more marked medial temporal atrophy |
ID 14 | 17/08/2011 | 11/11/2014 | 1182 | Generalised cerebral atrophy advanced for age. Supatentonial small vessel change static since 2013. No specific imaging features to indicate PSP |
ID 15 | 15/07/2012 | 07/06/2015 | 1057 | Moderate global cerebral atrophy for age. No other specific causes for cognitive impairment identified |
ID 16 | 06/09/2012 | 25/09/2012 | 19 | Generalised involutional change slightly excessive for age but no focal atrophy. No features of CJD. Posterior/medial temporal pattern of atrophy in keeping with a posterior dementia such as Alzheimer’s |
ID 17 | 15/07/2015 | 14/06/2017 | 700 | Advanced chronic small vessel vascular changes. Extensive atrophy, most evident in the medial temporal lobes |
ID 18 | 30/01/2017 | 26/04/2017 | 86 | Moderate volume loss and microvascular ischaemia |
ID 19 | 15/07/2014 | 12/10/2015 | 454 | Cerebral white matter and basal ganglia small vessel ischaemic changes, slightly prominent even allowing for age. Moderate generalised cerebral involution, slight more prominent in temporal lobes. Mixed vascular and neurodegenerative aetiology likely |
ID 20 | 28/06/2012 | 16/10/2013 | 475 | Asymmetrical atrophy, slight progression since 2009 |
ID 21 | 21/03/2017 | 20/04/2017 | 30 | Bilateral parietal volume loss |