Table 1 Characteristic of patients, univariate and multi-variate analysis of risk factors for BSI caused by CRKP compared with patients with BSI caused by CSKP
Total (n = 252) | CSKP (n = 223) | CRKP (n = 29) | P | OR | P | |
|---|---|---|---|---|---|---|
Demographic variables | ||||||
Male sex | 166(65.9) | 143(64.1) | 23(79.3) | 0.105 | ||
Age | ||||||
60–70 | 138(54.8) | 123(55.2) | 15(51.7) | 0.78 | ||
70–80 | 73(29.0) | 65(29.2) | 6(20.7) | 0.66 | ||
80–90 | 38(15.1) | 33(14.8) | 5(17.2) | 0.44 | ||
> 90 | 5(2.0) | 2(0.9) | 3(10.3) | 0.26 | ||
Co-morbidities | ||||||
Hypertension | 102(40.5) | 79(35.4) | 23(79.3) | < 0.001 | 13.789(3.883–48.969) | < 0.001 |
Diabetes mellitus | 68(27.0) | 57(25.6) | 11(37.9) | 0.158 | ||
Hematological tumors | 13(5.2) | 12(5.4) | 1(3.5) | 0.658 | ||
Solid organ tumors | 94(37.3) | 86(38.6) | 8(27.6) | 0.25 | ||
Previous bacterial infections | 102(40.5) | 85(38.1) | 17(58.6) | 0.034 | ||
Septic Shock | 37(14.7) | 31(13.9) | 6(20.7) | 0.331 | ||
Immunosuppression | 7(2.8) | 5(2.2) | 2(6.9) | 0.151 | ||
Organ dysfunction | 62(24.6) | 54(24.2) | 8(27.6) | 0.692 | ||
Antibiotics before KPN isolation | ||||||
β-Lactam/lactamase combinations | 29(11.5) | 21(9.4) | 8(27.6) | 0.009 | ||
cephalosporins | 47(18.6) | 35(15.7) | 12(41.4) | 0.001 | ||
carbapenems | 45(17.9) | 28(12.6) | 17(58.6) | < 0.001 | 8.073(2.066–31.537) | 0.003 |
quinolones | 23(9.1) | 19(8.5) | 4(13.8) | 0.354 | ||
Hospital stays before onset | 6(2,13) | 5(1,12) | 16(5,33) | 0.016 | ||
ICU stay | 59(23.4) | 38(17.0) | 21(72.4) | < 0.001 | 11.180(2.663–46.933) | 0.001 |
Pathogen isolated from other sites | 96(38.1) | 75(33.6) | 21(72.4) | < 0.001 | ||
Ward | ||||||
Internal medicine | 128(50.8) | 123(55.2) | 5(17.2) | 0.98 | ||
Surgical | 76(30.2) | 73(32.7) | 3(10.3) | 0.98 | ||
ICU | 48(19.1) | 27(12.1) | 21(72.4) | < 0.001 | ||
Invasive operation | ||||||
Surgery | 68(27.0) | 61(27.3) | 7(24.1) | 0.714 | ||
Puncture | 108(42.9) | 90(40.4) | 18(62.1) | 0.026 | ||
Catheter | 28(11.1) | 22(9.9) | 6(20.7) | 0.081 | ||
Mechanical ventilation | 31(12.3) | 18(8.1) | 13(44.8) | < 0.001 | ||
Mortality | 27(10.7) | 13(5.8) | 14(48.3) | < 0.001 | ||