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Table 2 Multiple logistic regression analysis of PIM use in each drug/drug group between 2012 and 2017

From: Prevalence of potentially inappropriate medications among old people with major neurocognitive disorder in 2012 and 2017

Drug groups

2012

2017

ORa (95% CI)

p-value

All people, n

20,889

35,212

  

Benzodiazepines, n (%)

434 (2.1)

511 (1.5)

0.731 (0.637–0.837)

 < 0.001

Anticholinergics, n (%)

1898 (9.1)

2098 (6.0)

0.657 (0.614–0.702)

 < 0.001

Tramadol, n (%)

367 (1.8)

114 (0.3)

0.195 (0.157–0.242)

 < 0.001

Propiomazine, n (%)

608 (2.9)

352 (1.0)

0.365 (0.318–0.419)

 < 0.001

Codeine, n (%)

546 (2.6)

408 (1.2)

0.440 (0.385–0.502)

 < 0.001

Glibenclamide, n (%)

197 (0.9)

87 (0.2)

0.269 (0.208–0.349)

 < 0.001

NSAIDs, n (%)

1024 (4.9)

941 (2.7)

0.562 (0.512–0.617)

 < 0.001

Antipsychotics, n (%)

2431 (11.6)

4323 (12.3)

1.148 (1.085–1.215)

 < 0.001

PIM (total), n (%)

5995 (28.7)

7629 (21.7)

0.724 (0.695–0.754)

 < 0.001

  1. CI confidence interval, NSAIDs non-steroidal anti-inflammatory drugs, OR odds ratio, PIM potentially inappropriate drug
  2. aAdjusted for sex (missing in 3 (2012) and 10 (2017) cases), age and baseline Mini Mental State Examination score (missing in 1,663 (2012) and 1,590 (2017) cases), reference category year 2012