Worsening functional status in nephrogeriatrics needs to be accounted for when clinically assessing CKD advancement in addition to GFR; supporting evidence based on the practical application of theoretical modelling

Table 5 ANOVA performed on variables between groups divided according to GFR

	Units	Inter-group variation	df	Intra-group variation	D f	F	p-value	η²	Int
Creatinine	mg/dl	358.8	2	158.9	110	124.19	< 0.005	0.69	Large
Urea	mg/dl	108,575.5	2	158,379.2	110	37.7	< 0.005	0.4	Large
GFR	ml/min/1,73m²	67,994.3	2	17,537.5	110	213.23	< 0.005	0.79	Large
Age	years	1481.7	2	51,544	110	15.81	< 0.005	0.22	Large
Comorbidities	number of diseases	97.8	2	490.7	110	10.95	< 0.005	0.16	Large
Medication	number of drugs	387	2	984	110	21.63	< 0.005	0.28	Large
Tinetti	points	139.1	2	4588.3	110	1.66	0.19	0.02	Small
IADL	points	11.3	2	332.4	110	1.87	0.16	0.03	Small
Barthel	points	549.4	2	39,222.8	110	0.77	0.47	0.01	Small

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