Table 3 Characteristics of users and non-users of oral anticoagulant on index date. Comorbidities were defined in relation to the index date
From: Prevalence of oral anticoagulant use among people with and without Alzheimer’s disease
Total = 138 470 | People with Alzheimer’s Disease (68 609) N (%) | People without Alzheimer’s Disease (69 861) N (%) | ||||
|---|---|---|---|---|---|---|
Users N = 15 961 | Non-Users N = 52 648 | P- Value | Users N = 13 918 | Non-users N = 55 943 | P- Value | |
Gender | < 0.001 | < 0.001 | ||||
Women, n (%) | 9 521 (59.7) | 35 198 (66.9) | 8 582 (61.7) | 36 909 (66.0) | ||
Men, n (%) | 6 440 (40.3) | 17 450 (33.1) | 5 336 (38.3) | 19 034 (34.0) | ||
Age (y), mean ± SD | 81.6 ± 5.8 | 79.5 ± 7.4 | < 0.001 | 82.0 ± 5.7 | 79.5 ± 7.3 | < 0.001 |
Occupational social class | < 0.001 | < 0.001 | ||||
Managerial/Professional | 3 082 (19.3) | 11 247 (21.4) | 2 662 (19.1) | 12 397 (22.2) | ||
Office | 1 123 (7.0) | 4 670 (8.9) | 1 037 (7.5) | 4 838 (8.6) | ||
Farming, Forestry | 3 435 (21.5) | 9 630 (18.3) | 3 209 (23.1) | 10 395 (18.6) | ||
Sales/Industrial/Cleaning | 6 940 (43.5) | 22 263 (42.3) | 5 677 (40.8) | 21 504 (38.4) | ||
Unknown | 1 381 (8.7) | 4 838 (9.2) | 1 333 (9.6) | 6 809 (12.2) | ||
Comorbidity | ||||||
Atrial fibrillation | < 0.001 | < 0.001 | ||||
< 6 months before | 2 384 (14.9) | 878 (1.7) | 1 454 (10.4) | 466 (0.8) | ||
6–12 months before | 720 (4.5) | 282 (0.5) | 645 (4.6) | 249 (0.4) | ||
More than 1 year before | 4 107 (25.7) | 1 840 (3.5) | 4 033 (29.0) | 1 703 (3.0) | ||
Coronary artery bypass grafting | < 0.001 | < 0.001 | ||||
< 6 months before | 24 (0.2) | 22 (0.04) | 59 (0.4) | 41 (0.07) | ||
6–12 months before | 23 (0.1) | 27 (0.05) | 23 (0.2) | 42 (0.08) | ||
Percutaneous coronary intervention | < 0.001 | < 0.001 | ||||
< 6 months before | 145 (0.9) | 24 (0.05) | 207 (1.5) | 32 (0.06) | ||
6–12 months before | 64 (0.4) | 41 (0.08) | 92 (0.7) | 57 (0.1) | ||
Ischemic stroke | < 0.001 | < 0.001 | ||||
< 6 months before | 610 (3.8) | 300 (0.6) | 423 (3.0) | 176 (0.3) | ||
6–12 months before | 270 (1.7) | 111 (0.2) | 231 (1.7) | 82 (0.1) | ||
Pulmonary embolism | < 0.001 | < 0.001 | ||||
< 6 months before | 119 (0.8) | 42 (0.08) | 106 (0.8) | 24 (0.04) | ||
6–12 months before | 50 (0.3) | 23 (0.04) | 53 (0.4) | 32 (0.06) | ||
Deep venous thrombosis | < 0.001 | < 0.001 | ||||
< 6 months before | 108 (0.7) | 48 (0.09) | 69 (0.5) | 33 (0.06) | ||
6–12 months before | 33 (0.2) | 32 (0.06) | 28 (0.2) | 31 (0.06) | ||
Hemorrhagic stroke | 0.39 | 0.99 | ||||
< 6 months before | 6 (0.04) | 15 (0.03) | -a | 9 (0.02) | ||
6–12 months before | -a | -a | -a | 8 (0.01) | ||