Fig. 2

Sensitivity analyses for risk of seizures according to duration of drug administration. Adjusted odds ratios with 95% confidence intervals for multivariable models to evaluate associations between cholinesterase inhibitor use and incident seizure within 12 months. Analysis was adjusted for the following covariates: comorbidities (cerebrovascular disease, diabetes with chronic complications, sleep disorders, hemi-/paraplegia, substance issues, Parkinsonism, renal failure, liver disease, and chronic pulmonary disease) and comedications (analgesics, antibacterials, anticholinergics, antidepressants, antifungals, antihistamines, anti-parkinsonian drugs, antipsychotics, antituberculosis drugs, benzodiazepines, glucocorticoids, and psychostimulants)