|
Model 1†
|
Model 2 (n = 295)
|
---|
Odds ratio for pre-frailty vs robustness (95% confidence interval)
|
Odds ratio per standard deviation increase (95% confidence interval)
|
p
|
Odds ratio for frailty vs robustness (95% confidence interval)
|
Odds ratio per standard deviation increase (95% confidence interval)
|
p
|
Odds ratio for pre-frailty vs robustness (95% confidence interval)
|
Odds ratio per standard deviation increase (95% confidence interval)
|
p
|
Odds ratio for frailty vs robustness (95% confidence interval)
|
Odds ratio per standard deviation increase (95% confidence interval)
|
p
|
---|
Inflammatory biomarkers
|
log CRP
|
1.46 (1.07–1.98)
|
1.62 (1.09–2.40)
|
0.02
|
1.53 (1.07–2.19)
|
1.74 (1.09–2.78)
|
0.02
|
1.59 (1.14–2.22)
|
1.83 (1.18–2.83)
|
0.007
|
1.20 (0.79–1.80)
|
1.26 (0.74–2.15)
|
0.39
|
log IL-6
|
1.17 (0.69–1.97)
|
1.13 (0.75–1.70)
|
0.56
|
2.01 (1.12–3.63)
|
1.72 (1.09–2.72)
|
0.02
|
0.85 (0.49–1.48)
|
0.88 (0.58–1.35)
|
0.57
|
1.58 (0.83–3.04)
|
1.43 (0.86–2.37)
|
0.17
|
Coagulation biomarkers
|
log tPA
|
1.90 (0.84–4.21)
|
1.34 (0.92–1.96)
|
0.13
|
1.39 (0.53–3.66)
|
1.16 (0.75–1.81)
|
0.51
|
–
|
log D-dimer
|
0.67 (0.38–1.18)
|
0.76 (0.52–1.12)
|
0.16
|
1.02 (0.54–1.91)
|
1.01 (0.66–1.55)
|
0.96
|
Endothelial biomarkers
|
log vWF
|
1.19 (0.60–2.35)
|
1.10 (0.77–1.56)
|
0.61
|
1.68 (0.75–3.73)
|
1.31 (0.86–1.99)
|
0.20
|
–
|
Cardiac biomarkers
|
log hs-cTnT
|
0.80 (0.46–1.38)
|
0.84 (0.56–1.27)
|
0.42
|
4.51 (2.11–9.63)
|
3.07 (1.74–5.40)
|
0.0001
|
0.69 (0.39–1.22)
|
0.76 (0.49–1.16)
|
0.20
|
4.06 (1.84–8.95)
|
2.84 (1.58–5.12)
|
0.0005
|
log NT-proBNP
|
0.83 (0.64–1.07)
|
0.73 (0.50–1.11)
|
0.15
|
1.13 (0.83–1.54)
|
1.22 (0.75–1.98)
|
0.42
|
–
|
- Model 1: Adjusted for age, eGFR, smoking status, polypharmacy, cognitive impairment, number of non-cardiovascular comorbidities, social class, BMI class, and systolic blood pressure. Model 2: also mutually-adjusted for biomarkers/imaging markers with p < 0.05 in Model 1
- BMI body mass index, eGFR estimated glomerular filtration rate, CRP C-reactive protein, IL-6 interleukin-6, tPA tissue plasminogen activator, vWF von Willebrand factor, hs-cTnT high-sensitivity cardiac troponin T, NT-proBNP N-terminal B-type natriuretic peptide
- †For Model 1, n varies by variable: log CRP n = 297, log IL-6 n = 301, log tPA n = 294, log D-dimer n = 294, log vWF n = 294, log hs-cTnT n = 298, log NT-proBNP n = 298