Table 3 Associations between frailty status and inflammatory/coagulation/endothelial/cardiac biomarkers in men with clinically-apparent CVD
|  | Model 1†| Model 2 (n = 295) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Odds ratio for pre-frailty vs robustness (95% confidence interval) | Odds ratio per standard deviation increase (95% confidence interval) | p | Odds ratio for frailty vs robustness (95% confidence interval) | Odds ratio per standard deviation increase (95% confidence interval) | p | Odds ratio for pre-frailty vs robustness (95% confidence interval) | Odds ratio per standard deviation increase (95% confidence interval) | p | Odds ratio for frailty vs robustness (95% confidence interval) | Odds ratio per standard deviation increase (95% confidence interval) | p | |
Inflammatory biomarkers | ||||||||||||
 log CRP | 1.46 (1.07–1.98) | 1.62 (1.09–2.40) | 0.02 | 1.53 (1.07–2.19) | 1.74 (1.09–2.78) | 0.02 | 1.59 (1.14–2.22) | 1.83 (1.18–2.83) | 0.007 | 1.20 (0.79–1.80) | 1.26 (0.74–2.15) | 0.39 |
 log IL-6 | 1.17 (0.69–1.97) | 1.13 (0.75–1.70) | 0.56 | 2.01 (1.12–3.63) | 1.72 (1.09–2.72) | 0.02 | 0.85 (0.49–1.48) | 0.88 (0.58–1.35) | 0.57 | 1.58 (0.83–3.04) | 1.43 (0.86–2.37) | 0.17 |
Coagulation biomarkers | ||||||||||||
 log tPA | 1.90 (0.84–4.21) | 1.34 (0.92–1.96) | 0.13 | 1.39 (0.53–3.66) | 1.16 (0.75–1.81) | 0.51 | – | |||||
 log D-dimer | 0.67 (0.38–1.18) | 0.76 (0.52–1.12) | 0.16 | 1.02 (0.54–1.91) | 1.01 (0.66–1.55) | 0.96 | ||||||
Endothelial biomarkers | ||||||||||||
 log vWF | 1.19 (0.60–2.35) | 1.10 (0.77–1.56) | 0.61 | 1.68 (0.75–3.73) | 1.31 (0.86–1.99) | 0.20 | – | |||||
Cardiac biomarkers | ||||||||||||
 log hs-cTnT | 0.80 (0.46–1.38) | 0.84 (0.56–1.27) | 0.42 | 4.51 (2.11–9.63) | 3.07 (1.74–5.40) | 0.0001 | 0.69 (0.39–1.22) | 0.76 (0.49–1.16) | 0.20 | 4.06 (1.84–8.95) | 2.84 (1.58–5.12) | 0.0005 |
 log NT-proBNP | 0.83 (0.64–1.07) | 0.73 (0.50–1.11) | 0.15 | 1.13 (0.83–1.54) | 1.22 (0.75–1.98) | 0.42 | – | |||||