Early-life exposure to Chinese famine and stroke risk in mid- to late life: the mediating roles of cognitive function and depression

Table 3 Percentages of the Association between Early-life Famine Exposure and Incident Adult Stroke Mediated by Cognitive Function and Depression in Adulthood in CHARLS, 2011–2015

Mediators	Proportion of the natural indirect effect explained ^a
	Fetally exposed		Childhood-exposed		Adolescence/adulthood-exposed
	%	95% CI	%	95% CI	%	95% CI
Cognitive function (M₁) ^b	2.43^*	0.65, 5.67	6.00^*	2.05, 16.91	5.42^*	1.80, 10.15
Depression (M₂) ^c	12.96	−3.37, 45.16	30.36^*	9.87, 87.44	22.13^*	10.00, 35.60
M₁ + M₂^d	15.38	−0.85, 48.75	36.35^*	14.19, 96.19	27.55^*	14.92, 40.02

CI confidence interval
^a Calculated as [natural indirect effect/(natural direct effect + natural indirect effect)]*100%
^b Stabilized weights accounted for age, sex, ethnicity, type of residence, childhood economic/health status, marital status, educational level, income, smoking, drinking, body mass index, depression, hypertension, dyslipidemia, and diabetes
^c Stabilized weights accounted for age, sex, ethnicity, type of residence, childhood economic/health status, marital status, educational level, income, smoking, drinking, body mass index, cognitive function, hypertension, dyslipidemia, and diabetes
^d Stabilized weights accounted for age, sex, ethnicity, type of residence, childhood economic/health status, marital status, educational level, income, smoking, drinking, body mass index, hypertension, dyslipidemia, and diabetes
*p < .05

ISSN: 1471-2318