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Table 3 Percentages of the Association between Early-life Famine Exposure and Incident Adult Stroke Mediated by Cognitive Function and Depression in Adulthood in CHARLS, 2011–2015

From: Early-life exposure to Chinese famine and stroke risk in mid- to late life: the mediating roles of cognitive function and depression

Mediators Proportion of the natural indirect effect explained a
Fetally exposed Childhood-exposed Adolescence/adulthood-exposed
% 95% CI % 95% CI % 95% CI
Cognitive function (M1) b 2.43* 0.65, 5.67 6.00* 2.05, 16.91 5.42* 1.80, 10.15
Depression (M2) c 12.96 −3.37, 45.16 30.36* 9.87, 87.44 22.13* 10.00, 35.60
M1 + M2d 15.38 −0.85, 48.75 36.35* 14.19, 96.19 27.55* 14.92, 40.02
  1. CI confidence interval
  2. a Calculated as [natural indirect effect/(natural direct effect + natural indirect effect)]*100%
  3. b Stabilized weights accounted for age, sex, ethnicity, type of residence, childhood economic/health status, marital status, educational level, income, smoking, drinking, body mass index, depression, hypertension, dyslipidemia, and diabetes
  4. c Stabilized weights accounted for age, sex, ethnicity, type of residence, childhood economic/health status, marital status, educational level, income, smoking, drinking, body mass index, cognitive function, hypertension, dyslipidemia, and diabetes
  5. d Stabilized weights accounted for age, sex, ethnicity, type of residence, childhood economic/health status, marital status, educational level, income, smoking, drinking, body mass index, hypertension, dyslipidemia, and diabetes
  6. *p < .05