Fig. 1

Orthogonal partial least squares discriminant analysis and summary of metabolites for sarcopenia and its components. (a)Scatter plot of OPLS-DA model analysis for sarcopenia (green circle) versus nonsarcopenia (blue circle) by the main components. (b)s-plot of OPLS-DA model of sarcopenia and nonsarcopenia. (c)Ordered list of metabolites with higher discrimination ability based on variable importance for the projection (VIP) score for separation of sarcopenia and nonsarcopenia.(d)Specific and overlapped metabolite for muscle parameters and sarcopenia(+ : positive association, -:negative association) Abbreviates:L1:1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine,L4:1-linoleoyl-2-hydroxy-sn-glycero-3-phosphocholine,L2:1-stearoyl-2-hydroxy-sn-glycero-3-phosphocholine,L3:1-oleoyl-2-hydroxy-sn-glycero-3-phosphocholine,A9:glycine,A10:alanine,A1:valine,A5:phenylalanine A6:tryptophan,A7:glutamine,A3:leucine,A4:tyrosine,A2:Ileucine,A8:glutamate,C0:carnitine, C2:acetylcarnitine,C3:propionyl-L-carnitine,C5:valeryl-L-carnitine,C6:AcyCNhexenoyl-L-carnitine,C8:octanoyl-L-carnitine,C10:decanoyl-L-carnitin,C10:1:decenoyl-L-carnitine,C12:dodecanoy-L-carnitine,C14:tetradecanoyl-L-car-nitine,C16:hexadec-C16anoyl-L-carnitine,C18:octadecanoyl-L-carnitine,C18:1:octadecenoyl-L-carnitine