Table 5 Differences in impairment among participants by age category compared to participants < 45 years of age, presented as estimate or odds ratio (OR) when indicated with (95% confidence interval) and p-values for each outcome. Estimates that are statistically significant (p < 0.05) are bolded
Outcome; estimate type | Baseline difference Est [95% CI] P-value | Week 18 difference* Est [95% CI] P-value | ||
|---|---|---|---|---|
Age category | 45–59 | 60 or greater | 45–59 | 60 or greater |
10-Time Chair Rise Test | ||||
 Unable to complete due to physical ability or safety concerns; OR | 1.5 [0.3, 11.3] P = 0.68 | 3.4 [0.8, 23.7] P = 0.14 |  |  |
 Time to complete; seconds | −2.3 [−9.5, 4.9] P = 0.52 | −3.3 [−10.4, 3.8] P = 0.36 |  |  |
 Change in time to complete from week 2/6; seconds |  |  | −2.7 [−7.9, 2.6] P = 0.31 | −5.1 [−10.3, 0] P = 0.05 |
Clinical Frailty Scale | ||||
 Post-hospitalization reported frailty; OR | 3.2 [0.7, 18.0] P = 0.15 | 2.5 [0.6, 9.9] P = 0.18 |  |  |
 Did not return to pre-hospitalization frailty; OR |  |  | 0.3 [0.1, 1.3] P = 0.11 | 0.3 [0.8, 1.1] P = 0.09 |
MRC Dyspnea Scale | ||||
 Too SOB to leave the house and/or SOB while dressing; OR | 0.6 [0.2, 2.5] P = 0.48 | 2.4 [0.8, 8.5] P = 0.14 |  |  |
 No improvement from week 2–6 answer; OR |  |  | 0.7 [0.2, 3.2] P = 0.65 | 0.3 [0.1, 1.2] P = 0.09 |
IES-6 | ||||
 Met criteria for PTSD; OR | 1.5 [0.4, 5.8] P = 0.51 | 1.6 [0.5, 5.4] P = 0.43 |  |  |
 Continued or new PTSD; OR |  |  | 0.3 [0.1, 1.2] P = 0.10 | 0.3 [0.1, 1.0] P = 0.05 |
WHODAS 2.0 | ||||
 Total score | −1.1 [−7.5, 5.2] P = 0.72 | 3.4 [−2.4, 9.2] P = 0.25 |  |  |
 Difference from week 2–6; score |  |  | 0.2 [−6.8, 7.1] P = 0.96 | 2.3 [−4.2, 8.8] P = 0.47 |
Supplemental O2 | ||||
 Reported use; OR | 0.9 [0.3, 2.8] P = 0.91 | 1.3 [0.5, 3.7] P = 0.61 |  |  |
 Continued or new use of supplemental O2; OR |  |  | 1.7 [0.3, 13.3] P = 0.58 | 2.8 [0.6, 20.0] P = 0.24 |
Activity Level | ||||
 Did not return to pre-hospitalization exercise; OR |  |  | 0.3 [0.1, 1.7] P = 0.19 | 0.3 [0.1, 1.1] P = 0.07 |