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Table 2 Number and percentage of single diseases and multimorbidity stratified by sex and birth phases for the whole participants (n = 3,377) from KORA-Age 1 and KORA-Age 3

From: Impact of prenatal and childhood adversity effects around World War II on multimorbidity: results from the KORA-Age study

Disease

Total (3,377)

Sex

Birth phases

Male (1,616)

Female (1,761)

P-value

Pre-war (684)

Early war (1,236)

Late war (283)

Famine (574)

After famine (600)

P-value

Multimorbidity (MM)

1667 (49.4%)

788 (48.8%)

879 (49.9%)

0.503

370 (54.1%)

561 (45.4%)

176 (62.2%)

310 (54.0%)

250 (41.7%)

 < 0.001

Lung

343 (10.2%)

157 (9.7%)

186 (10.6%)

0.415

61 (8.9%)

109 (8.8%)

35 (12.4%)

71 (12.4%)

67 (11.2%)

0.065

Joint diseases( Arthritis. Rheumatic)

349 (10.3%)

119 (7.4%)

230 (13.1%)

 < 0.001

74 (10.8%)

138 (11.2%)

31 (11.0%)

52 (9.1%)

54 (9.0%)

 < 0.001

Cancer

145 (4.3%)

74 (4.6%)

71 (4.0%)

0.433

25 (3.7%)

55 (4.4%)

13 (4.6%)

27 (4.7%)

25 (4.2%)

0.898

Gastrointestinal

270 (8%)

109 (6.7%)

161 (9.1%)

0.0101

61 (8.9%)

97 (7.8%)

21 (7.4%)

49 (8.5%)

42 (7.0%)

0.735

Heart diseases

637 (18.9%)

371 (23%)

266 (15.1%)

 < 0.001

149 (21.8%)

216 (17.5%)

65 (23.0%)

121 (21.1%)

86 (14.3%)

 < 0.001

Stroke

165 (4.9%)

110 (6.8%)

55 (3.1%)

 < 0.001

34 (5.0%)

52 (4.2%)

27 (9.5%)

32 (5.6%)

20 (3.3%)

 < 0.001

Kidney

117 (3.5%)

62 (3.8%)

55 (3.1%)

0.257

30 (4.4%)

34 (2.8%)

18 (6.4%)

24 (4.2%)

11 (1.8%)

0.002

Liver

82 (2.4%)

43 (2.7%)

39 (2.2%)

0.400

15 (2.2%)

29 (2.3%)

9 (3.2%)

15 (2.6%)

14 (2.3%)

0.913

Diabetes mellitus

504 (14.9%)

276 (17.1%)

228 (12.9%)

 < 0.001

118 (17.3%)

165 (13.3%)

48 (17.0%)

95 (16.6%)

78 (13.0%)

0.056

Neurological disease

103 (3.1%)

51 (3.2%)

52 (3.0%)

0.731

22 (3.2%)

31 (2.5%)

10 (3.5%)

20 (3.5%)

20 (3.3%)

0.727

Hypertension

1914 (56.7%)

910 (56.3%)

1004 (57.0%)

0.626

396 (57.9%)

673 (54.4%)

179 (63.3%)

344 (59.9%)

322 (53.7%)

0.013

Eye disease

866 (25.6%)

364 (22.5%)

502 (28.5%)

 < 0.001

202 (29.5%)

285 (23.1%)

103 (36.4%)

164 (28.6%)

112 (18.7%)

 < 0.001

Anxiety

192 (5.7%)

55 (3.4%)

137 (7.8%)

 < 0.001

55 (8.0%)

87 (7.0%)

9 (3.2%)

24 (4.2%)

17 (2.8%)

 < 0.001

Depression

44 (1.3%)

16 (1.0%)

28 (1.6%)

0.131

12 (1.8%)

15 (1.2%)

3 (1.1%)

9 (1.6%)

5 (0.8%)

0.616

  1. P-value from Chi-square test for categorical variables. Phases were defined based on participant’s critical developmental age (prenatal gestation or the first two years of life) and the World War II situation in Germany