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Table 2 Laboratory results according to clinical outcomes

From: Chronic diseases, chest computed tomography, and laboratory tests as predictors of severe respiratory failure and death in elderly Brazilian patients hospitalized with COVID-19: a prospective cohort study

Variables
(n. %)
Total
(n = 201)
Mechanical Ventilation (n = 34) No MV
(n = 167)
p Death
(n = 16)
No death
(n = 185)
p
Laboratory tests abnormalities (in quartiles)
 Higher CRP (mg/L) 51 (25.4) 19 (55.9) 32 (19.2) < 0.001 9 (56.3) 42 (22.7) 0.006
 Higher IL-6 (pg/mL) 49 (24.4) 15 (44.1) 34 (20.4) 0.004 9 (56.3) 40 (21.6) 0.004
 Higher d-Dimer (ng/mL) 51 (25.4) 18 (52.9) 33 (19.8) < 0.001 10 (62.5) 41 (22.2) 0.001
 Higher ALT (U/mL) 51 (25.4) 9 (26.5) 42 (25.1) 0.512 3 (18.8) 48 (25.9) 0.384
Higher AST (U/mL) 51 (25.4) 16 (47.1) 35 (21.0) 0.002 6 (37.5) 45 (24.3) 0.191
 Lower Hemoglobin (g/mL) 51 (25.4) 18 (52.9) 33 (19.8) < 0.001 10 (62.5) 41 (22.2) 0.001
 Higher Leucocytes (/μL) 49 (24.4) 12 (35.3) 37 (22.2) 0.082 7 (43.8) 42 (22.7) 0.063
 Higher Creatinine (mg/dL) 50 (24.9) 14 (41.2) 36 (21.6) 0.017 9 (56.3) 41 (22.2) 0.005
 Higher Myoglobin (ng/mL) 50 (25.0) 19 (55.9) 31 (18.7) < 0.001 9 (56.3) 41 (22.3) 0.005
 Lower Vitamin D (ng/dL) 48 (23.9) 45 (26.9) 3 (8.8) 0.026 2 (12.5) 46 (24.9) 0.215
 Lower Lymphocytes (/μL) 49 (24.4) 17 (50.0) 32 (19.2) < 0.001 6 (37.5) 43 (23.2) 0.165
Laboratories variables (means ± SD)
 CRP (mg/L) 54.88 (58.92) 94.97 (68.87) 46.71 (53.32) < 0.001 98.28 (67.97) 51.12 (56.73) 0.002
 IL-6 (pg/mL) 39.50 (60.58) 83.87 (99.40) 30.46 (44.41) < 0.001 96.58 (85.19) 34.56 (55.59) 0.000
 D-Dimer (ng/mL) 886.16 (1002.79) 1426.05 (1432.77) 776.25 (855.34) 0.002 1382.06 (977.41) 843.28 (995.95) 0.039
 ALT (U/mL) 39.45 (33.84) 37.88 (27.89) 39.77 (34.99) 0.767 37.00 (33.70) 39.67 (33.94) 0.763
 AST (U/mL) 35.20 (23.53) 47.00 (30.85) 32.80 (21.06) 0.001 50.87 (39.25) 33.84 (21.29) 0.005
 Hemoglobin (g/mL) 12.77 (1.94) 11.73 (2.16) 12.98 (1.83) 0.001 11.23 (2.18) 12.90 (1.86) 0.001
 Leucocytes (/μL) 7012.95 (3410.39) 8552.08 (3246.08) 6699.60 (3366.65) 0.004 9013.12 (3116.15) 6839.97 (3387.12) 0.014
 Creatinine (mg/dL) 1.05 (0.63) 1.31 (0.865) 1.00 (0.56) 0.009 1.27 (0.48) 1.03 (0.64) 0.146
 Myoglobin (ng/mL) 68.25 (147.88) 163.19 (328.13) 48.81 (51.03) < 0.001 135.82 (180.03) 62.38 (143.84) 0.057
 Vitamin D (ng/dL) 33.01 (15.47) 28.41 (9.98) 33.95 (16.22) 0.057 29.62 (9.89) 33.30 (15.84) 0.362
 Lymphocytes (/μL) 1019.56 (599.60) 697.61 (403.83) 1085.10 (612.52) 0.001 863.62 (427.83) 1033.04 (611.20) 0.279
  1. Legend: C-reactive protein (CRP), interleukin 6 (IL-6), alanine transaminase (ALT), aspartate aminotransferase (AST)