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Table 3 Cognitive abilities and neuropsychological tests used in assessment in included studiesa

From: Is there an association between non-alcoholic fatty liver disease and cognitive function? A systematic review

Cognitive abilities

Neuropsychological testsb

Cognitive impairment seen in NAFLD

No difference seen in NAFLD

Study

General Cognition

Montreal Cognitive Assessment test Serbian version

+

 

Filipovic et al. 2018 [21]

Montreal Cognitive Assessment Turkish version

+

 

Celikbilek et al. 2018 [22]

Mini Mental State Examination

+

 

Tuttolomondo et al. 2018 [33]

Cognitive Failures Questionnaire

+

 

Elliott et al. 2013 [23]

Reasoning

Raven’s Progressive Matrices

 

–

Tarter et al. 1984 [30]

Mental speed, Attention and Psychomotor speed

Digit Symbol Substitution Test

+

 

Weinstein et al. 2018 [27]

MoCA-TR Attention: Sustained attention task

 

–

Celikbilek et al. 2018 [22]

MoCA-TR Attention: A serial subtraction task

 

–

Celikbilek et al. 2018 [22]

MoCA-TR Attention: Digits forward and backward tasks

 

–

Celikbilek et al. 2018 [22]

Digit span forward

 

–

Tarter et al. 1984 [30]

Digit span backward

 

–

Tarter et al. 1984 [30]

Mental control

 

–

Tarter et al. 1984 [30]

Purdue Pegboard

+

 

Tarter et al. 1984 [30]

Stary Tracing

 

–

Tarter et al. 1984 [30]

Symbol Digit Substitution Test

+

 

Seo et al. 2016 [32]

The Simple Reaction Time Test

+

 

Seo et al. 2016 [32]

Symbol Digit Modalities Test

+

 

Tarter et al. 1984 [30]

The number connection test A

 

–

Felipo et al. 2012 [24]

The number connection test B

 

–

Felipo et al. 2012 [24]

 

The Serial Dotting Test

 

–

Felipo et al. 2012 [24]

Memory and learning

The Wechsler Memory Scale (verbal and visual)

 

–

Weinstein et al. 2019 [29]

Logical memory

 

–

Tarter et al. 1984 [30]

Figural memory

 

–

Tarter et al. 1984 [30]

Paired associates

 

–

Tarter et al. 1984 [30]

Supraspan - Weschler Memory Scale

 

–

Tarter et al. 1984 [30]

Supraspan Learning Test

+

 

Tarter et al. 1987 [31]

Digit Span Test

 

–

Tarter et al. 1987 [31]

Benton Visual Retention Test

+

 

Tarter et al. 1987 [31]

Rey-Osterreith Complex Figure Test

 

–

Tarter et al. 1987 [31]

Brown-Peterson Test

 

–

Tarter et al. 1987 [31]

The Serial Digit Learning Test

+

 

Seo et al. 2016 [32]

Language

Fluency

 

–

Tarter et al. 1984 [30]

Confrontation Naming

 

–

Tarter et al. 1984 [30]

Responsive Naming

 

–

Tarter et al. 1984 [30]

Peabody Picture Intelligence Test

 

–

Tarter et al. 1984 [30]

A Verbal Fluency Task

+

 

Takahashi et al. 2017 [28]

The Token Test

 

–

Tarter et al. 1984 [30]

Visuospatial perception

MoCA-TR Visuospatial abilities: Clock drawing

+

 

Celikbilek et al. 2018 [22]

MoCA-SR visuoconstructive: Draw a cube and a clock in 11:10 position of clock hands

+

 

Filipovic et al. 2018 [21]

MoCA-TR Visuospatial abilities: Three-dimensional cube-copying task

+

 

Celikbilek et al. 2018 [22]

Hooper Visual Organization Test

 

–

Weinstein et al. 2019 [29]

Block Design

 

–

Tarter et al. 1984 [30]

Tactual Performance

+

 

Tarter et al. 1984 [30]

The Line Tracing Test

 

–

Felipo et al. 2012 [24]

Ideas, abstraction, figural creations and mental flexibility

The Animal Fluency Test

+

 

Weinstein et al. 2018 [27]

Trail Making

+

 

Tarter et al. 1984 [30]

MoCA-TR Executive functioning abilities: Trail Making B task

+

 

Celikbilek et al. 2018 [22]

MoCA-TR Executive functioning abilities: Phonemic fluency task

+

 

Celikbilek et al. 2018 [22]

MoCA-TR Executive functioning abilities: Two-item verbal abstraction task

+

 

Celikbilek et al. 2018 [22]

Time to complete trail-making B minus time to complete trail-making A test

+

 

Weinstein et al. 2019 [29]

The Similarities Test

+

 

Weinstein et al. 2019 [29]

  1. aAbbreviations: MOCA-TR Montreal Cognitive Assessment Turkish, MOCA-SR Montreal Cognitive Assessment Serbian, NAFLD Non-alcoholic fatty liver disease, NASH Non-alcoholic steatohepatitis, MMSE Mini mental state examination, T2DM Type 2 diabetes mellitus, CFQ Cognitive failures questionnaire, VFT Verbal fluency task
  2. bPlus (+) = impaired cognitive function observed in NAFLD for specific cognitive test. Negative (−) = no association or similar association observed in NAFLD for specific cognitive test