Exercise priming with transcranial direct current stimulation: a study protocol for a randomized, parallel-design, sham-controlled trial in mild cognitive impairment and Alzheimer’s disease

Table 2 Schedule of assessments

	Screening/ Baseline	Midpoint	Endpoint^a	Follow-up
Visit	T1 Study initiation	T2 3-weeks	T3 5-weeks / study endpoint	T4 Within 2 weeks of T3
*Demographics*
Clinical diagnosis of mild or major NCD due to AD or mixed AD/vascular disease following the DSM-5 criteria by a psychiatrist	X
Demographics	X
Surgical and health history	X
Comorbid Illnesses and concomitant medications	X	X	X
Sleep, caffeine, alcohol intake, smoking status	X	X	X
Standardized mini-mental state examination	X
Canadian society of exercise physiology physical activity readiness questionnaire-plus	X
*Outcomes*
Montreal cognitive assessment	X	X	X
Word recognition task	X	X	X
Word recall task	X	X	X
n-back	X	X	X
Neuropsychiatric inventory	X	X	X
Blood biomarkers	X	X	X
Safety
Adverse Events	X	X	X
Other
Leisure-time exercise questionnaire^b	X	X	X
Follow-up assessment with qualified investigator or designated qualified physician				X

^aThis visit will also take place if the patient withdraws from study or is terminated early
^bThe Leisure-Time Exercise Questionnaire will be administered weekly during the study

ISSN: 1471-2318