Table 1 Demographic data and baseline characteristics of patients included in the cohort, stratified by drug-drug interaction (DDI) status at baseline
Total N = 1950 | At least one DDI at baselinea N = 1045 | No DDI at baselinea N = 905 | Missing values | P value | |
|---|---|---|---|---|---|
Age (years) | |||||
Median (IQR) | 79 [74–84] | 78 [74–83] | 79 [74–85] | 0 | .13 .25 |
70–79 | 1053 (54) | 582 (56) | 471 (52) | ||
80–89 | 757 (39) | 393 (37) | 364 (40) | ||
> 90 | 140 (7) | 70 (7) | 70 (8) | ||
Male | 1080 (55) | 558 (53) | 522 (58) | 0 | .06 |
Trial site | |||||
Louvain, Belgium | 385 (20) | 206 (20) | 179 (20) | 0 | .25 |
Cork, Ireland | 328 (17) | 171 (16) | 157 (17) | ||
Utrecht, The Netherlands | 433 (22) | 250 (24) | 183 (20) | ||
Bern, Switzerland | 804 (41) | 418 (40) | 386 (43) | ||
Medical history | |||||
Dementia | 116 (6) | 65 (6) | 51 (6) | 0 | .65 |
Depression | 173 (9) | 132 (13) | 41 (5) | < .001 | |
Stroke | 410 (21) | 207 (20) | 203 (22) | .17 | |
Hypertension | 1282 (66) | 675 (65) | 607 (67) | .27 | |
Atrial fibrillation | 697 (36) | 436 (42) | 261 (29) | < .001 | |
Diabetes | 628 (32) | 346 (33) | 282 (31) | .38 | |
Coronary artery disease | 661 (34) | 385 (37) | 276 (31) | .004 | |
Heart failure | 500 (26) | 333 (32) | 167 (19) | < .001 | |
Chronic renal failure | 522 (27) | 302 (29) | 220 (24) | .03 | |
Chronic hepatic failure | 98 (5) | 41 (4) | 57 (6) | .02 | |
COPD | 375 (19) | 258 (25) | 117 (13) | < .001 | |
Cancer | 482 (25) | 249 (24) | 233 (26) | .35 | |
Bleeding | 250 (13) | 137 (13) | 113 (12) | .73 | |
Thromboembolic disease | 236 (12) | 133 (13) | 103 (11) | .40 | |
Number of comorbidities | 11 [8–16] | 11 [8–16] | 11 [8–15] | .002 | |
Medications on index admission | |||||
Number of drugs per day | 12 [9–16] | 14 [11–18] | 11 [8–14] | 0 | < .001 |
Hyperpolypharmacyb | 1458 (75) | 873 (83) | 585 (65) | ||
Any hospitalizations during the previous year Number of hospitalizations during the previous year | 986 (51) 1 [0–1] | 566 (54) 1 [0–2] | 420 (46) 0 [0–1] | 0 | .001 < .001 |
Not living independentlyc | 375 (19) | 222 (21) | 153 (17) | 0 | .02 |
ADL6 score | 5.5 [4.5–6.0] | 5.5 [4.5–6.0] | 5.5 [4.5–6.0] | 32 | .61 |
Education level | |||||
Less than high school education | 573 (30) | 326 (32) | 247 (28) | 24 | .16 |
High-school degree | 886 (46) | 463 (45) | 423 (47) | ||
Post-secondary degree | 467 (24) | 243 (23) | 224 (25) | ||
Type of admission | |||||
Electived | 473 (24) | 243 (23) | 230 (25) | 0 | .29 |
Non-elective | 1477 (76) | 802 (77) | 675 (75) | ||
Main reason for hospital admission | |||||
Surgical | 257 (13) | 120 (11) | 137 (15) | 0 | .02 |
Medical | 1693 (87) | 925 (89) | 768 (85) | ||