Serum concentrations of oxytocin, DHEA and follistatin are associated with osteoporosis or sarcopenia in community-dwelling postmenopausal women

Table 4 Correlation of history of fragile fracture, lifestyle and serum biomarkers with osteoporosis or sarcopenia by Logistic Regression

Variables	Osteoporosis		Sarcopenia
Variables	OR(95% CI)	P value	OR(95% CI)	P-value
History of fragile fracture (no vs. fracture)	0.30 (0.05–0.71)	0.006	0.45 (0.01–0.86)	0.015
Physical exercise (no vs. high)	0.97 (0.44–3.13)	0.94	1.07 (0.24–2.51)	0.69
Milk consumption (no vs. high)	1.39 (0.57–3.34)	0.46	6.32 (1.04–38.29)	0.045
DHEA (ng/ml)	0.75 (0.61–1.05)	0.06	0.73 (0.51–0.96)	0.032
T2	0.89 (0.63–1.24)	0.62	0.78 (0.44–2.22)	0.72
E2	0.67 (0.33–2.65)	0.58	0.90 (0.46–3.12)	0.65
PTH (pg/ml)	1.01 (0.97–1.04)	0.64	0.97 (0.90–1.04)	0.36
25OHD(ng/ml)	0.98 (0.93–1.07)	0.22	0.51 (0.11–0.82)	0.047
CTX (pg/ml)	1.02 (0.98–1.05)	0.17	1.02 (0.92–1.12)	0.78
PINP (ng/ml)	1.12 (0.97–1.48)	0.51	1.07 (0.95–1.17)	0.31
Follistatin (ng/ml)	1.08 (0.56–2.09)	0.17	1.66 (1.19–3.57)	0.022
Myostatin (ng/ml)	0.95 (0.90–1.13)	0.82	1.01 (0.98–1.03)	0.56
BDNF (ng/ml)	0.78 (0.38–1.62)	0.50	0.35 (0.07–1.82)	0.35
Oxytocin (pg/ml)	0.75 (0.63–0.98)	0.019	0.88 (0.57–1.01)	0.14

Multivariate logistic analysis was performed after adjusting for age. DHEA Dehydroepiandrosterone, PTH Parathyroid hormone, CTX C-telopeptide collagen crosslinks, P1NP N-terminal propeptide of type 1 collagen, BDNF Brain-derived neurotrophic factor

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