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Table 3 Results from the generalized linear mixed modela for antidepressants, antipsychotics, anxiolytics, sedatives/hypnotics, and antidementia drugs

From: Do prescription rates of psychotropic drugs change over three years from nursing home admission?

Covariate

Antidepressants

Antipsychotics

Anxiolytics

Sedatives and hypnotics

Antidementia drugs

Reg. coeff. (SE)

p-value

Reg. coeff. (SE)

p-value

Reg. coeff. (SE)

p-value

Reg. coeff. (SE)

p-value

Reg. coeff. (SE)

p-value

Time

0.07 (0.02)

< 0.001

0.04 (0.03)

0.157

0.06 (0.02)

0.005

−0.03 (0.03)

0.358

0.01 (0.02)

0.561

Time*Time

−0.001 (0.0006)

0.023

−0.001 (0.0008)

0.150

−0.001 (0.0006)

0.029

0.0009 (0.001)

0.374

−0.001 (0.0007)

0.135

OR (95% CI)

p-value

OR (95% CI)

p-value

OR (95% CI)

p-value

OR (95% CI)

p-value

OR (95% CI)

p-value

Age

0.93 (0.90–0.97)

< 0.001

0.96 (0.92–0.99)

0.023

0.98 (0.95–1.01)

0.172

1.02 (0.99–1.05)

0.213

0.97 (0.93–1.00)

0.062

Gender, female

2.09 (1.26–3.47)

0.005

1.17 (0.64–2.15)

0.608

0.99 (0.59–1.65)

0.961

0.90 (0.56–1.45)

0.676

1.01 (0.59–1.74)

0.973

Charlson Comorbidity Index

1.02 (0.91–1.14)

0.748

0.96 (0.60–1.53)

0.097

0.97 (0.87–1.09)

0.640

0.99 (0.89–1.09)

0.810

0.86 (0.75–0.98)

0.023

GMHR, Poor/Fair

1.04 (0.73–1.50)

0.824

0.96 (0.60–1.53)

0.851

1.17 (0.79–1.73)

0.440

0.74 (0.52–1.06)

0.104

0.78 (0.52–1.15)

0.207

PSMS

0.85 (0.72–1.01)

0.070

0.90 (0.72–1.13)

0.358

0.99 (0.82–1.19)

0.890

0.85 (0.72–1.01)

0.059

1.16 (0.96–1.39)

0.121

CDR sob

0.98 (0.93–1.04)

0.519

1.02 (0.95–1.09)

0.597

0.98 (0.93–1.04)

0.464

0.89 (0.85–0.94)

< 0.001

1.03 (0.97–1.09)

0.337

CSDD

1.05 (1.00–1.10)

0.045

0.98 (0.93–1.04)

0.590

1.02 (0.97–1.07)

0.411

−0.06 (0.03)b

0.040

0.95 (0.90–1.00)

0.075

 CSDD * Time

      

0.01 (0.004)b

0.010

  

 CSDD * Time * Time

      

−0.0003 (0.0001)b

0.014

  

NPI-agitation

1.00 (0.96–1.03)

0.868

1.00 (0.96–1.04)

0.980

1.01 (0.98–1.04)

0.626

0.99 (0.96–1.02)

0.446

0.97 (0.94–1.01)

0.136

NPI-psychosis

0.98 (0.93–1.03)

0.391

1.11 (1.05–1.17)

< 0.001

1.02 (0.97–1.07)

0.515

0.98 (0.93–1.04)

0.549

1.04 (0.98–1.09)

0.212

NPI-affective

1.09 (1.04–1.14)

< 0.001

1.03 (0.98–1.08)

0.227

1.05 (1.01–1.10)

0.026

1.04 (0.99–1.08)

0.083

1.00 (0.96–1.05)

0.929

NPI-caregivers

1.00 (0.95–1.04)

0.851

1.00 (0.95–1.05)

0.998

0.99 (0.94–1.03)

0.581

1.03 (0.98–1.08)

0.201

1.03 (0.98–1.09)

0.222

QUALID

0.97 (0.94–1.01)

0.094

1.01 (0.97–1.06)

0.541

1.02 (0.98–1.05)

0.416

1.03 (0.99–1.06)

0.134

1.00 (0.96–1.04)

0.827

NPI-apathy

1.04 (0.98–1.11)

0.175

1.00 (0.93–1.08)

0.984

0.98 (0.92–1.05)

0.657

1.03 (0.97–1.10)

0.265

0.93 (0.86–1.00)

0.039

Type of unit: special care unit

0.81 (0.50–1.30)

0.379

1.32 (0.75–2.34)

0.332

1.58 (0.98–2.57)

0.062

1.54 (0.96–2.45)

0.071

1.78 (1.09–2.90)

0.021

No. patients/unit

0.97 (0.93–1.00)

0.080

1.00 (0.95–1.05)

0.996

1.03 (0.99–1.07)

0.190

1.01 (0.98–1.05)

0.523

0.97 (0.93–1.01)

0.196

No. hours physician/unit

1.02 (0.97–1.07)

0.490

1.01 (0.95–1.07)

0.764

1.01 (0.97–1.06)

0.591

0.98 (0.93–1.03)

0.449

1.00 (0.95–1.06)

0.957

  1. Bold text: statistically significant results. GMHR General Medical Health Rating Scale, PSMS Physical Self-Maintenance Scale, CDR sob Clinical Dementia Rating scale sum of boxes, CSDD Cornell Scale for Depression in Dementia, NPI Neuropsychiatric Inventory, QUALID Quality of Life in Late-Stage Dementia. NPI-subsyndromes are calculated as the sum the following items: NPI-Agitation = Agitation + Disinhibition + Irritability, NPI-Psychosis = Delusions + Hallucinations, NPI-Affective = Depression + Anxiety
  2. a Multiple model; N = 1853(N = 476 at BL, N = 362 at 6m, N = 307 at 12m, N = 241 at 18m, N = 195 at 24m, N = 148 at 30m, N = 124 at 36m)
  3. b Regression coefficient (SE) reported because of interaction
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BMC Geriatrics

ISSN: 1471-2318

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