Interaction between cognitive leisure activity and long-chain polyunsaturated fatty acid intake on global cognitive decline in a Japanese longitudinal cohort study: National Institute for Longevity Sciences-Longitudinal Study of Aging

Table 4 Interaction between each CLA and intake of each fatty acid

CLA	LCPUFA			DHA			EPA			ARA
	Estimate	SE	Interaction	Estimate	SE	Interaction	Estimate	SE	Interaction	Estimate	SE	Interaction
			P-Value			P-Value			P-Value			P-Value
Reading books	0.66	0.69	0.34	0.81	0.69	0.24	0.69	0.69	0.32	−0.30	0.65	0.65
Writing	−0.35	0.46	0.45	−0.13	0.45	0.78	−0.25	0.46	0.58	0.05	0.45	0.91
Creative activities	−0.36	0.46	0.43	−0.38	0.46	0.40	−0.38	0.46	0.41	−0.41	0.46	0.37
Art appreciation	−1.15	0.53	0.03	−1.22	0.53	0.02	−0.76	0.51	0.14	−1.29	0.54	0.02
Gardening	0.22	0.52	0.67	0.52	0.52	0.32	0.04	0.512	0.94	−0.54	0.52	0.29

Note: Multiple logistic analysis adjusted for sex; age; MMSE score; BMI; education level; marital status; smoking status; alcohol consumption; energy intake; physical activity; employment status; depressive tendency; and history of hypertension, hyperlipidemia, ischemic heart disease, stroke, and diabetes. Fatty acid intake was divided into two groups (high, low) based on the median and according to sex. CLA was divided into two groups based on frequency of participation: “at least once or more per month” (high); and “once or several times per year or less” (low)
ARA, arachidonic acid; CLA, cognitive leisure activity; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; LCPUFA, long-chain polyunsaturated fatty acids

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