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Table 2 Adjusted association of Charlson Comorbidity Index with hospitalization, ICU admission, mechanical ventilation and death, stratified by age group

From: Age differences in the association of comorbid burden with adverse outcomes in SARS-CoV-2

 

18-64 years N=99,483

65-79 years N=55,013

≥80 years N=26,032

All patients N=170,528

 

Adjustedab hazard ratio (95% confidence intervals)

Adjustedab hazard ratio (95% confidence intervals)

Adjustedab hazard ratio (95% confidence intervals)

Adjustedab hazard ratio (95% confidence intervals)

P for interaction with age group

Hospitalization

 Number of hospitalizations

8,110

11,907

4,676

24,693

 

 30-day cumulative incidence of hospitalization (per 100 patients)

8.2

21.7

29.5

14.5

< 0.001***

 Median length of stay (IQR), days

4 (2-8)

6 (3-13)

8 (4-15)

6 (3-12)

 

Charlson Comorbidity Index

    

< 0.001***

 0

1

1

1

1

 

 1

1.40 (1.31-1.51)***

1.19 (1.07-1.31)**

0.91 (0.77-1.08)

1.37 (1.29-1.44)***

 

 2-3

1.86 (1.73-1.99)***

1.48 (1.36-1.62)***

1.01 (0.88-1.17)

1.75 (1.66-1.84)***

 

 ≥4

3.35 (3.13-3.58)***

2.51 (2.31-2.73)***

1.55 (1.36-1.78)***

2.91 (2.77-3.05)***

 

ICU admission

 Median Length of stay (IQR), days

4 (1-7)

4 (2-10)

4 (2-8)

4 (2-9)

 

 Number of ICU admissions

2,705

4,709

1,712

9,126

< 0.001***

 30-day cumulative incidence of ICU admission (per 100 patients)

2.7

8.6

11

5.4

 

Charlson Comorbidity Index

    

< 0.001***

 0

1

1

1

1

 

 1

1.25 (1.10-1.42)***

1.11 (0.94-1.30)

0.92 (0.70-1.23)

1.25 (1.14-1.37)***

 

 2-3

1.70 (1.51-1.92)***

1.33 (1.16-1.53)***

0.91 (0.71-1.16)

1.60 (1.47-1.74)***

 

 ≥4

3.43 (3.05-3.85)***

2.36 (2.08-2.69)***

1.51 (1.21-1.89)***

2.88 (2.66-3.12)***

 

Mechanical ventilation

    

< 0.001***

 Number receiving mechanical ventilation

1,017

2,109

490

3,616

 

 30-day incidence of mechanical ventilation (per 100 patients)

1

3.9

3.2

2.1

 

Charlson Comorbidity Index

    

< 0.001***

 0

1

1

1

1

 

 1

0.91 (0.73-1.13)

0.97 (0.78-1.20)

0.55 (0.33-0.93)*

1.06 (0.92-1.23)

 

 2-3

1.41 (1.16-1.70)***

1.00 (0.83-1.21)

0.76 (0.51-1.13)

1.44 (1.27-1.64)***

 

 ≥4

2.72 (2.26-3.26)***

1.69 (1.43-2.01)***

1.03 (0.71-1.48)

2.43 (2.16-2.74)***

 

Death

    

< 0.001***

 Number of deaths

770

3,897

3,255

7,922

 

 30-day cumulative incidence of death (per 100 patients)

0.8

7.1

20.3

4.6

 

Charlson Comorbidity Index

    

< 0.001***

 0

1

1

1

1

 

 1

0.98 (0.75-1.29)

1.34 (1.12-1.60)**

1.05 (0.88-1.26)

1.29 (1.15-1.44)***

 

 2-3

1.74 (1.38-2.20)***

1.45(1.25-1.70)***

1.08 (0.92-1.27)

1.53 (1.38-1.69)***

 

 ≥4

3.26 (2.61-4.08)***

2.48 (2.14-2.86)***

1.41 (1.22-1.64)***

2.35 (2.14-2.59)***

 
  1. a Adjusted for Federal Emergency Management Agency region: 1 (Connecticut, Massachusetts, Maine, New Hampshire, Rhode Island, Vermont), 2 (New Jersey, New York, Puerto Rico), 3 (District of Columbia, Delaware, Maryland, Pennsylvania, Virginia, West Virginia), 4 (Alabama, Florida, Georgia, Kentucky, Mississippi, North Carolina, South Carolina, Tennessee), 5 (Illinois, Indiana, Michigan, Minnesota, Ohio, Wisconsin), 6 (Arkansas, Louisiana, New Mexico, Oklahoma, Texas), 7 (Iowa, Kansas, Missouri, Nebraska), 8 (Colorado, Montana, North Dakota, South Dakota, Utah, Wyoming), 9 (Arizona, California, Guam, Hawaii, Nevada), 10 (Alaska, Idaho, Oregon, Washington) and all characteristics listed in Table 1 with the exception that age was modeled as a continuous variable.
  2. bStratified by station.
  3. *P<0.05, **P<0.01, ***P<0.001
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