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Table 2 Adjusted association of Charlson Comorbidity Index with hospitalization, ICU admission, mechanical ventilation and death, stratified by age group

From: Age differences in the association of comorbid burden with adverse outcomes in SARS-CoV-2

  18-64 years N=99,483 65-79 years N=55,013 ≥80 years N=26,032 All patients N=170,528  
Adjustedab hazard ratio (95% confidence intervals) Adjustedab hazard ratio (95% confidence intervals) Adjustedab hazard ratio (95% confidence intervals) Adjustedab hazard ratio (95% confidence intervals) P for interaction with age group
Hospitalization
 Number of hospitalizations 8,110 11,907 4,676 24,693  
 30-day cumulative incidence of hospitalization (per 100 patients) 8.2 21.7 29.5 14.5 < 0.001***
 Median length of stay (IQR), days 4 (2-8) 6 (3-13) 8 (4-15) 6 (3-12)  
Charlson Comorbidity Index      < 0.001***
 0 1 1 1 1  
 1 1.40 (1.31-1.51)*** 1.19 (1.07-1.31)** 0.91 (0.77-1.08) 1.37 (1.29-1.44)***  
 2-3 1.86 (1.73-1.99)*** 1.48 (1.36-1.62)*** 1.01 (0.88-1.17) 1.75 (1.66-1.84)***  
 ≥4 3.35 (3.13-3.58)*** 2.51 (2.31-2.73)*** 1.55 (1.36-1.78)*** 2.91 (2.77-3.05)***  
ICU admission
 Median Length of stay (IQR), days 4 (1-7) 4 (2-10) 4 (2-8) 4 (2-9)  
 Number of ICU admissions 2,705 4,709 1,712 9,126 < 0.001***
 30-day cumulative incidence of ICU admission (per 100 patients) 2.7 8.6 11 5.4  
Charlson Comorbidity Index      < 0.001***
 0 1 1 1 1  
 1 1.25 (1.10-1.42)*** 1.11 (0.94-1.30) 0.92 (0.70-1.23) 1.25 (1.14-1.37)***  
 2-3 1.70 (1.51-1.92)*** 1.33 (1.16-1.53)*** 0.91 (0.71-1.16) 1.60 (1.47-1.74)***  
 ≥4 3.43 (3.05-3.85)*** 2.36 (2.08-2.69)*** 1.51 (1.21-1.89)*** 2.88 (2.66-3.12)***  
Mechanical ventilation      < 0.001***
 Number receiving mechanical ventilation 1,017 2,109 490 3,616  
 30-day incidence of mechanical ventilation (per 100 patients) 1 3.9 3.2 2.1  
Charlson Comorbidity Index      < 0.001***
 0 1 1 1 1  
 1 0.91 (0.73-1.13) 0.97 (0.78-1.20) 0.55 (0.33-0.93)* 1.06 (0.92-1.23)  
 2-3 1.41 (1.16-1.70)*** 1.00 (0.83-1.21) 0.76 (0.51-1.13) 1.44 (1.27-1.64)***  
 ≥4 2.72 (2.26-3.26)*** 1.69 (1.43-2.01)*** 1.03 (0.71-1.48) 2.43 (2.16-2.74)***  
Death      < 0.001***
 Number of deaths 770 3,897 3,255 7,922  
 30-day cumulative incidence of death (per 100 patients) 0.8 7.1 20.3 4.6  
Charlson Comorbidity Index      < 0.001***
 0 1 1 1 1  
 1 0.98 (0.75-1.29) 1.34 (1.12-1.60)** 1.05 (0.88-1.26) 1.29 (1.15-1.44)***  
 2-3 1.74 (1.38-2.20)*** 1.45(1.25-1.70)*** 1.08 (0.92-1.27) 1.53 (1.38-1.69)***  
 ≥4 3.26 (2.61-4.08)*** 2.48 (2.14-2.86)*** 1.41 (1.22-1.64)*** 2.35 (2.14-2.59)***  
  1. a Adjusted for Federal Emergency Management Agency region: 1 (Connecticut, Massachusetts, Maine, New Hampshire, Rhode Island, Vermont), 2 (New Jersey, New York, Puerto Rico), 3 (District of Columbia, Delaware, Maryland, Pennsylvania, Virginia, West Virginia), 4 (Alabama, Florida, Georgia, Kentucky, Mississippi, North Carolina, South Carolina, Tennessee), 5 (Illinois, Indiana, Michigan, Minnesota, Ohio, Wisconsin), 6 (Arkansas, Louisiana, New Mexico, Oklahoma, Texas), 7 (Iowa, Kansas, Missouri, Nebraska), 8 (Colorado, Montana, North Dakota, South Dakota, Utah, Wyoming), 9 (Arizona, California, Guam, Hawaii, Nevada), 10 (Alaska, Idaho, Oregon, Washington) and all characteristics listed in Table 1 with the exception that age was modeled as a continuous variable.
  2. bStratified by station.
  3. *P<0.05, **P<0.01, ***P<0.001