Outcomes | Age < 65 years (n = 51,071) | Age ≥ 65 years (n = 28,816) | ||
HR | 95 % CI | HR | 95 % CI | |
No FRAIL item | 1 | – | 1 | – |
1 item | 1.16 | 1.08–1.24a | 1.17 | 1.06–1.28b |
2 items | 1.23 | 1.11–1.37b | 1.22 | 1.10–1.36b |
≥ 3 items | 1.05 | 0.71–1.54 | 1.54 | 1.25–1.88a |
Per 1 item increase | 1.11 | 1.06–1.16a | 1.10 | 1.05–1.15a |
 |  | Female (n = 24,240) | Male (n = 55,647) | |
HR | 95 % CI | HR | 95 % CI | |
No FRAIL item | 1 | – | 1 | – |
1 item | 1.21 | 1.11–1.31a | 1.17 | 1.09–1.26a |
2 items | 1.31 | 1.18–1.46a | 1.19 | 1.08–1.31b |
≥ 3 items | 1.51 | 1.14–1.99b | 1.32 | 1.06–1.65c |
Per 1 item increase | 1.14 | 1.08–1.20a | 1.09 | 1.04–1.14b |
 | Earlier stage CKD (n = 78,486) | Stage 5 CKD (n = 1,401) | ||
HR | 95 % CI | HR | 95 % CI | |
No FRAIL item | 1 | – | 1 | – |
1 item | 1.19 | 1.13–1.26a | 1.17 | 0.76–1.78 |
2 items | 1.24 | 1.16–1.34a | 1.28 | 0.73–2.25 |
≥ 3 items | 1.42 | 1.19–1.69a | 2.15 | 0.57–8.07 |
Per 1 item increase | 1.11 | 1.07–1.15a | 1.16 | 0.89–1.51 |