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Table 2 ORs and 95% CIs for the Risk of post-stroke cognitive impairment According to sST2 quartiles

From: Soluble ST2 and risk of cognitive impairment after acute ischemic stroke: a prospective observational study

 

sST2, pg/mL

p value for trend

< 117.60

117.60–163.51

163.51–238.77

≥238.77

Median

89.75

139.13

196.13

349.14

 

Cognitive impairment: MoCA

 Cases, n (%)

63 (40.7)

79 (51.3)

81 (51.9)

102 (66.2)

< 0.001

 Model 1

1.00

1.48 (0.93–2.35)

1.56 (0.98–2.48)

2.53 (1.55–4.12)

< 0.001

 Model 2

1.00

1.57 (0.96–2.55)

1.64 (1.01–2.68)

2.35 (1.40–3.93)

0.002

 Model 3

1.00

1.58 (0.97–2.56)

1.65 (1.01–2.70)

2.38 (1.42–4.00)

0.002

Cognitive impairment: MMSE

 Cases, n (%)

69 (44.5)

73 (47.4)

81 (51.9)

100 (64.9)

< 0.001

 Model 1

1.00

1.04 (0.66–1.66)

1.28 (0.80–2.04)

1.93 (1.19–3.14)

0.003

 Model 2

1.00

1.09 (0.67–1.76)

1.31 (0.81–2.12)

1.76 (1.06–2.92)

0.021

 Model 3

1.00

1.10 (0.68–1.78)

1.33 (0.82–2.16)

1.82 (1.09–3.03)

0.016

  1. MoCA score of < 23 or MMSE score of < 27 indicates cognitive impairment
  2. Model 1: adjusted for age, sex, and education level;
  3. Model 2: adjusted for model 1 and further adjusted for current smoking, alcohol drinking, time from onset to randomization, systolic blood pressure, baseline National Institutes of Health Stroke Scale score, baseline modified Rankin Scale score, medical history (hypertension, diabetes mellitus, hyperlipidemia, and coronary heart disease), use of antihypertensive medications, randomized treatment, ischemic stroke subtype, anticoagulant treatment and hypoglycemic treatment
  4. Model 3: adjusted for model 2 and further adjusted for hsCRP
  5. Abbreviations: sST2 soluble suppression of tumorigenicity 2, MoCA Montreal Cognitive Assessment, MMSE Mini-Mental State Examination, OR odds ratio
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BMC Geriatrics

ISSN: 1471-2318

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