Table 2 Analysis of primary outcome, knee-extension strength (n = 21)
Primary outcome | Baseline Mean (SD) | Follow-up Mean (SD) | Within-group difference Mean (95% CI) | Between-group difference Mean (95% CI) | |||
|---|---|---|---|---|---|---|---|
Modified intention-to-treat | |||||||
INT (n = 11) | CON (n = 10) | INT (n = 11) | CON (n = 10) | INT (n = 11) | CON (n = 10) | ||
Strength, Fractured (Nm/kg) | 0.56 (0.38) | 0.72 (0.36) | 1.17 (0.46) | 1.23 (0.39) | 0.61 (0.34;0.88) | 0.50 (0.21;0.79) | 0.11 (− 0.25; 0.48) |
Strength, non-fractured (Nm/kg) | 1.07 (0.45) | 1.27 (0.26) | 1.35 (0.39) | 1.40 (0.39) | 0.28 (0.20;0.37) | 0.13 (− 0.07;0.32) | 0.16 (− 0.05; 0.36) |
Strength, fractured % non-fractured (%) | 50.5 (21.6) | 59.4 (31.0) | 84.6 (15.4) | 89.1 (16.2) | 34.1 (16.5;51.6) | 29.7 (9.0;50.3) | 4.4 (−20.7; 29.5) |
Per protocol | |||||||
Exercisea | (n = 8) | (n = 10) | (n = 8) | (n = 10) | (n = 8) | (n = 10) | |
Strength, Fractured (Nm/kg) | 0.62 (0.42) | 0.73 (0.37) | 1.35 (0.40) | 1.23 (0.39) | 0.72 (0.42;1.03) | 0.50 (0.21;0.79) | 0.23 (−0.16; 0.61) |
Strength, non-fractured (Nm/kg) | 1.15 (0.50) | 1.27 (0.26) | 1.45 (0.40) | 1.40 (0.39) | 0.29 (0.19;0.40) | 0.13 (− 0.07;0.32) | 0.17 (− 0.04; 0.37) |
Injections | (n = 7) | (n = 9) | (n = 7) | (n = 9) | (n = 7) | (n = 9) | |
Strength, Fractured (Nm/kg) | 0.36 (0.17) | 0.69 (0.37) | 1.14 (0.45) | 1.25 (0.40) | 0.78 (0.47;1.09) | 0.56 (0.26;0.85) | 0.22 (−0.17;0.61) |
Strength, non-fractured (Nm/kg) | 1.00 (0.48) | 1.29 (0.26) | 1.33 (0.39) | 1.39 (0.41) | 0.33 (0.23;0.42) | 0.10 (−0.11;0.31) | 0.22 (0.01;0.44)* |
Exercise + injections | (n = 5) | (n = 9) | (n = 5) | (n = 9) | (n = 5) | (n = 9) | |
Strength, Fractured (Nm/kg) | 0.38 (0.17) | 0.69 (0.37) | 1.27 (0.48) | 1.25 (0.40) | 0.89 (0.49;1.29) | 0.56 (0.26;0.85) | 0.34 (−0.10;0.77) |
Strength, non-fractured (Nm/kg) | 1.05 (0.57) | 1.29 (0.26) | 1.36 (0.47) | 1.39 (0.41) | 0.32 (0.18;0.46) | 0.10 (−0.11;0.31) | 0.22 (−0.07;0.50) |