Effects of an interprofessional Quality Circle-Deprescribing Module (QC-DeMo) in Swiss nursing homes: a randomised controlled trial

Table 3 Effect of the intervention on the outcomes

	Regression coefficient	95% confidence interval	p-value
Primary outcomes
% of PIM galenic units	−0.014	[−0.038;+0.010]	0.240
Number of PIM DDD/res	−0.183	[−0.392;+0.025]	0.083
Secondary outcomes
Number of DDD/res to avoid	−0.035	[−0.095;+0.025]	0.252
Number of DDD/res to reevaluate	−0.237	[− 0.435;−0.040]	0.020
Safety outcomes
Mortality rate ^a
Intervention group	−12.7%	[−21.5%;−4.0%]	0.005
Geriatric mission	+8.7%	[+0.8%;+16.6%]	0.032
Group × mission	−11.4%	[−23.3%;+0.05%]	0.060
Days in hospital (n = 51) ^a,b
Intervention group	+1.551	[+0.164;+2.938]	0.029
Geriatric mission	−1.381	[−2.670;−0.091]	0.036
Group × mission	+1.910	[+ 0.020;+3.799]	0.048
Number of falls (n = 46) ^b	−0.165	[−0.754;+0.424]	0.575
Rate of physical restraints use (n = 46)	−4.2%	[−16.0%;+7.6%]	0.479

All data are difference between intervention and control group at follow-up, estimated using linear regression models, under adjustment for outcome baseline value, canton, mission and size of the NH. n = 55, unless otherwise specified. PIM potentially inappropriate medication, DDD/res defined daily dose per average resident and per day. ^a: also adjusted for the interaction between group and mission, as it proved significant. ^b: reported per average resident and per year

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