Table 1 Comparison of incident antidepressant initiators and noninitiators with and without PD. Comorbidities and university hospital district represent data on index date (date of Parkinson’s disease diagnosis)
Parkinson’s disease n = 20,546 | No Parkinson’s disease n = 140,291 | ||||||
|---|---|---|---|---|---|---|---|
Initiators (n = 9091) | Non-initiators (n = 11,455) | P* | Initiators (n = 35,083) | Non-initiators (n = 105,208) | P* | P ** | |
Age at the beginning of follow-up mean (95% CI) | 62.8 (62.5–63.0) | 63.1 (63.0–63.3) | 0.005 | 63.6 (63.5–63.7) | 62.3 (62.3–62.4) | < 0.001 | < 0.001 |
Sex (men) (n, %) | 4332 (47.7) | 7134 (62.3) | < 0.001 | 15,986 (45.6) | 62,399 (59.3) | < 0.001 | < 0.001 |
Comorbidities | |||||||
History of depression | 924 (10.2) | 152 (1.3) | < 0.001 | 2680 (7.6) | 1163 (1.1) | < 0.001 | < 0.001 |
Cardiovascular disease | 3585 (39.4) | 4414 (38.5) | 0.19 | 14,937 (42.6) | 38,377 (36.5) | < 0.001 | < 0.001 |
Diabetes | 1143 (12.6) | 1490 (13.0) | 0.36 | 4769 (13.6) | 12,434 (11.8) | < 0.001 | 0.011 |
Asthma/COPD | 713 (7.8) | 768 (6.7) | 0.002 | 3134 (8.9) | 7166 (6.8) | < 0.001 | 0.001 |
Rheumatoid arthritis | 309 (3.4) | 375 (3.3) | 0.62 | 1477 (4.2) | 3662 (3.5) | < 0.001 | < 0.001 |
University hospital district | < 0.001 | < 0.001 | 0.25 | ||||
Helsinki | 2777 (30.6) | 3169 (27.7) | 10,458 (29.8) | 30,480 (29.0) | |||
Kuopio | 1698 (18.7) | 2142 (18.7) | 6593 (18.8) | 19,245 (18.3) | |||
Oulu | 1221 (13.4) | 1675 (14.6) | 4792 (13.7) | 14,865 (14.1) | |||
Tampere | 2164 (23.8) | 2831 (24.7) | 8561 (24.4) | 25,753 (24.5) | |||
Turku | 1193 (13.1) | 1573 (13.7) | 4578 (13.1) | 14,231 (13.5) | |||
Other (Åland) | 38 (0.4) | 65 (0.6) | 101 (0.3) | 634 (0.6) | |||
Age at initiation (mean, 95% CI) | 70.6 (70.4–70.9) | 71.9 (71.8–72.0) | < 0.001 | ||||
Number of purchased antidepressants | 0.39 | ||||||
1 | 9028 (99.3) | 34,868 (99.4) | |||||
2 | 63 (0.7) | 215 (0.6) | |||||
Antidepressant group | |||||||
SSRIs | 4899 (53.9) | 16,973 (48.4) | < 0.001 | ||||
Mirtazapine | 2460 (27.1) | 10,620 (30.3) | < 0.001 | ||||
TCAs | 958 (10.5) | 4760 (13.6) | < 0.001 | ||||
SNRIs | 422 (4.6) | 1711 (4.9) | 0.35 | ||||
Other | 410 (4.5) | 1208 (3.4) | < 0.001 | ||||