Table 1 Study SPIRIT diagram

 Eligibility screening checklist

X

 Informed consent

X

 Allocation (L+/L-)

X

 Demographics and characteristics

X

 Wound assessment and medical health history

X

 X

 PROMIS Cognitive Function 6a

X

X

X

 PROMIS Global Health Scale - 10 item

X

X

X

 PROMIS Anxiety 6a

X

X

X

 PROMIS Fatigue 6a

X

X

X

 PROMIS Pain Interference 6b

X

X

X

 PROMIS Sleep Disturbance 6a

X

X

X

 Katz Activities of Daily Living - 6 item

X

X

X

 Mini-nutritional status - 7 item

X

X

X

 UCLA Loneliness Scale - 20 item

X

X

X

 Medical Outcomes Social Support Survey - 19 item

X

X

X

 Patient Health Questionnaire - 9 item

X

X

X

 The Stigma Scale: Body Image and the Skin - 8 item

X

X

X

 Blood Sample: RNA for deep sequencing analysis*

X

X

X