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Table 3 Clinical features of study participants classified by renal function

From: Association between renal function and platelet reactivity during aspirin therapy in elderly patients with atherosclerotic cardiovascular disease

Variables

G1 group (N = 49; eGFR ≥90 mL/min/1.73 m2)

G2 group (N = 160; eGFR 60–89 mL/min/1.73 m2)

G3 group (N = 95; eGFR 30–59 mL/min/1.73 m2)

P value

P value

G1 vs. G2

G1 vs. G3

G2 vs. G3

eGFR, mL/min/1.73m2

94.5 ± 7.3

74.2 ± 8.5

50.8 ± 7.9

< 0.001

< 0.001

< 0.001

< 0.001

HTPR, n (%)

6 (12.2)

36 (22.5)

34 (35.8)

0.005

0.117

0.003

0.021

LTA-AA, %

7.75 ± 4.07

9.90 ± 3.83

10.92 ± 4.63

< 0.001

0.002

< 0.001

0.058

Age, years

67 ± 7

76 ± 7

82 ± 5

< 0.001

< 0.001

< 0.001

< 0.001

Diastolic blood pressure, mmHg

77 ± 11

72 ± 10

69 ± 10

< 0.001

0.007

< 0.001

0.025

Hemoglobin, g/dl

14.0 ± 1.6

13.4 ± 1.4

12.4 ± 1.7

< 0.001

0.013

< 0.001

< 0.001

Neutrophil percentage, %

61.1 ± 10.2

59.9 ± 9.4

65.6 ± 9.6

< 0.001

0.458

0.007

< 0.001

PLT, × 103/uL

190 ± 55

186 ± 50

169 ± 47

0.012

0.626

0.016

0.008

MPV, fl

9.4 ± 1.4

8.6 ± 1.1

8.7 ± 1.0

< 0.001

0.004

0.016

0.886

MPV/PLT ratio, fl × 10−3uL

0.053 ± 0.018

0.050 ± 0.016

0.056 ± 0.018

0.031

0.248

0.393

0.009

Serum creatinine, mg/dL

0.70 (0.62–0.80)

0.95 (0.85–1.03)

1.21 (1.12–1.32)

< 0.001

< 0.001

< 0.001

< 0.001

Serum urea, mg/dL

31.9 ± 8.0

38.0 ± 9.2

47.0 ± 14.7

< 0.001

0.007

< 0.001

< 0.001

Serum uric acid, mg/dL

5.12 ± 1.32

5.52 ± 1.22

6.04 ± 1.37

< 0.001

0.059

< 0.001

0.002

C-reactive protein, mg/L

0.5 (0.3–1.3)

0.6 (0.3–1.3)

1.4 (0.7–4.1)

< 0.001

0.988

0.006

< 0.001

Medical history

 Ischemic stroke/TIA, n (%)

9 (18.4)

48 (30.0)

38 (40.0)

0.026

0.110

0.009

0.102

 Peripheral artery stenosis, n (%)

0 (0)

19 (11.9)

17 (17.9)

0.007

0.011

0.002

0.182

 Hypertension, n (%)

33 (67.3)

118 (73.8)

81 (85.3)

0.031

0.432

0.020

0.053

 Hyperlipidemia, n (%)

35 (71.4)

137 (85.6)

88 (92.6)

0.003

0.023

0.001

0.093

Medications taken

 ACEIs/ARBs, n (%)

20 (40.8)

83 (51.9)

59 (61.2)

0.046

0.175

0.015

0.112

 Statins, n (%)

34 (69.4)

152 (95.0)

88 (92.6)

< 0.001

< 0.001

< 0.001

0.437

 Diuretics, n (%)

5 (10.2)

17 (10.6)

22 (23.2)

0.015

0.993

0.059

0.007

 Proton pump inhibitors, n (%)

2 (4.1)

32 (20.0)

28 (29.5)

0.002

0.008

< 0.001

0.085

  1. LTA-AA Light transmission assay with arachidonic acid, eGFR Estimated glomerular filtration rate, PLT Platelet count, MPV Mean platelet volume, TIA Transient ischemic attacks, ACEIs Angiotensin converting enzyme inhibitors, ARBs Angiotensin receptor blockers
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