Variables | G1 group (N = 49; eGFR ≥90 mL/min/1.73 m2) | G2 group (N = 160; eGFR 60–89 mL/min/1.73 m2) | G3 group (N = 95; eGFR 30–59 mL/min/1.73 m2) | P value | P value | ||
---|---|---|---|---|---|---|---|
G1 vs. G2 | G1 vs. G3 | G2 vs. G3 | |||||
eGFR, mL/min/1.73m2 | 94.5 ± 7.3 | 74.2 ± 8.5 | 50.8 ± 7.9 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
HTPR, n (%) | 6 (12.2) | 36 (22.5) | 34 (35.8) | 0.005 | 0.117 | 0.003 | 0.021 |
LTA-AA, % | 7.75 ± 4.07 | 9.90 ± 3.83 | 10.92 ± 4.63 | < 0.001 | 0.002 | < 0.001 | 0.058 |
Age, years | 67 ± 7 | 76 ± 7 | 82 ± 5 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Diastolic blood pressure, mmHg | 77 ± 11 | 72 ± 10 | 69 ± 10 | < 0.001 | 0.007 | < 0.001 | 0.025 |
Hemoglobin, g/dl | 14.0 ± 1.6 | 13.4 ± 1.4 | 12.4 ± 1.7 | < 0.001 | 0.013 | < 0.001 | < 0.001 |
Neutrophil percentage, % | 61.1 ± 10.2 | 59.9 ± 9.4 | 65.6 ± 9.6 | < 0.001 | 0.458 | 0.007 | < 0.001 |
PLT, × 103/uL | 190 ± 55 | 186 ± 50 | 169 ± 47 | 0.012 | 0.626 | 0.016 | 0.008 |
MPV, fl | 9.4 ± 1.4 | 8.6 ± 1.1 | 8.7 ± 1.0 | < 0.001 | 0.004 | 0.016 | 0.886 |
MPV/PLT ratio, fl × 10−3uL | 0.053 ± 0.018 | 0.050 ± 0.016 | 0.056 ± 0.018 | 0.031 | 0.248 | 0.393 | 0.009 |
Serum creatinine, mg/dL | 0.70 (0.62–0.80) | 0.95 (0.85–1.03) | 1.21 (1.12–1.32) | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Serum urea, mg/dL | 31.9 ± 8.0 | 38.0 ± 9.2 | 47.0 ± 14.7 | < 0.001 | 0.007 | < 0.001 | < 0.001 |
Serum uric acid, mg/dL | 5.12 ± 1.32 | 5.52 ± 1.22 | 6.04 ± 1.37 | < 0.001 | 0.059 | < 0.001 | 0.002 |
C-reactive protein, mg/L | 0.5 (0.3–1.3) | 0.6 (0.3–1.3) | 1.4 (0.7–4.1) | < 0.001 | 0.988 | 0.006 | < 0.001 |
Medical history | |||||||
Ischemic stroke/TIA, n (%) | 9 (18.4) | 48 (30.0) | 38 (40.0) | 0.026 | 0.110 | 0.009 | 0.102 |
Peripheral artery stenosis, n (%) | 0 (0) | 19 (11.9) | 17 (17.9) | 0.007 | 0.011 | 0.002 | 0.182 |
Hypertension, n (%) | 33 (67.3) | 118 (73.8) | 81 (85.3) | 0.031 | 0.432 | 0.020 | 0.053 |
Hyperlipidemia, n (%) | 35 (71.4) | 137 (85.6) | 88 (92.6) | 0.003 | 0.023 | 0.001 | 0.093 |
Medications taken | |||||||
ACEIs/ARBs, n (%) | 20 (40.8) | 83 (51.9) | 59 (61.2) | 0.046 | 0.175 | 0.015 | 0.112 |
Statins, n (%) | 34 (69.4) | 152 (95.0) | 88 (92.6) | < 0.001 | < 0.001 | < 0.001 | 0.437 |
Diuretics, n (%) | 5 (10.2) | 17 (10.6) | 22 (23.2) | 0.015 | 0.993 | 0.059 | 0.007 |
Proton pump inhibitors, n (%) | 2 (4.1) | 32 (20.0) | 28 (29.5) | 0.002 | 0.008 | < 0.001 | 0.085 |