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Table 4 Most common mmedications requiring dose adjustment or precautions, defined by the CG equation

From: Medication burden and inappropriate prescription risk among elderly with advanced chronic kidney disease

CategoryMedicationsPatients (%)
dose modification is recommended based on ClCrAllopurinol167 (30)
Atenolol34 (6.1)
Acebutolol31 (5.6)
Lorazepama31 (5.6)
Hydroxyzinea27 (4.9)
Perindopril20 (3.6)
Bromazepama17 (3.1)
Tianeptine15 (2.7)
dose modification based on CrCl is not recommanded but a maximum daily dose is mentionnedRamipril70 (12.6)
Nebivolol56 (10.1)
Simvastatin37 (6.7)
no specific recommendationsBisoprolol93 (16.7)
Clopidogrel91 (16.4)
Fluindione72 (12.9)
Pravastatin53 (9.5)
Repaglinide35 (6.1)
Candesartan31 (5.6)
Warfarin15 (2.7)
Clonazepam14 (2.5)
Celiprolol14 (2.5)
  1. CrCl Creatinine clearance
  2. aLorazepam, Hydroxyzine and Bromazepam are both Renally Inappropriate Medications (RIM) and Potentially Inappropriate-for-the-elderly Medication (PIM)