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Table 1 Schedule of enrolment, assessments and close-out

From: GERO Cohort Protocol, Chile, 2017–2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly

   Enrolment Assessment Close-out
TIMEPOINT   -t1 t1 t2 t3
ENROLMENT:      
Eligibility screen
Informed consent
  X    
  X    
ASSESSMENTS:
Functionality
Technological - Activities of Daily Living Questionnaire (T-ADLQ) [30]. X   X X
Everyday Cognition Scale (ECog) [31]. X   X X
Pfeffer Functional Activities Questionnaire (PQAF) [29]. X   X X
Socio-demographic a [67] Marital status.   X X X
Education.   X   
Occupational background.   X   
Ethnicity.   X   
Individual and household income.   X X X
Assets inventory.   X X X
Health insurance.   X X X
Household conformation.   X X X
Social network information.   X X X
Health, risk factors, anthropometric and laboratory assessment b Health related quality of life (EQ-5D) [32].   X X X
Tabacum and alcohol consumption (Alcohol Use Disorders Identification Test, AUDIT) [33].   X X X
Audition and vision section of the Chilean National Health Survey [34].   X X X
Physical activity, sedentarism and diet [34].   X X X
Oral health thought the Oral Health Impact Profile (OHIP).   X X X
Frailty: Fried Frailty Phenotype and the Frail Questionnaires [35, 36].   X X X
Anthropometric measurements: weight, body mass index (BMI), systolic and diastolic blood pressure (seat and standing).   X X X
Framingham Cardiovascular Risk Scale.   X X X
Laboratory evaluation: hemogram, glycaemia, lipid profile, level of vitamin B12 and folic acid, thyroid hormone (TSH and free T4) and hepatic profile.   X X X
Health inventory on 18 health conditions (including cardiovascular events).   X X X
Psychological assessment c Engagement in stimulating activities.   X X X
Ageing related losses.   X X X
Personality traits [37, 38].   X X X
Psychological well-being [39].   X X X
Geriatric Depression Scale - Brink and Yesavage [40].   X X X
Depression, Anxiety and Stress Scale (DASS-21) [41].   X X X
Coping processes [42].   X X X
Social integration.   X X X
Cognitive reserve scale [43].   X X X
Stage and clinical symptoms d Clinical Dementia Rating for Frontotemporal Lobar Degeneration (CDR-FTLD)-eight domains [44]. X   X X
Alzheimer Disease- 8 (AD8) [45, 46]. X   X X
Neuropsychological evaluation Global Cognitive Function:     
- Minimental-State Examination (MMSE) [47]. X   X X
- Montreal Cognitive Examination (MoCA) [48]. X   X X
- Addenbrooke’s Cognitive Examination (ACE III) [49].   X X X
Memory:
- Short Term Memory Binding Test [50, 51].
- Free and Cued Selective Reminding Test (FCRST) [52,53,54]
- Supermarket task [55].
  X X X
Executive functions:
- Ineco Frontal Screening [56].
- Verbal fluency test [57].
- Color Trail Test Part B [58, 59].
  X X X
Language: Sydney Language Battery (Sydbat) [60].   X X X
Visuo-constructive abilities: Rey Complex Fig [61, 62]..   X X X
Social Cognition: MiniSea [63].   X X X
Motor assessment e Soft neurological signs:
-Heidelberg Neurological Soft Signs [64].
-Edinburgh Motor Assessment (EMAS) [65].
  X X X
Balance: simple-task, dual-task (including cognitive task), and sensorimotor task.   X X X
Walking assessment: carrying a cup with water, and counting backwards from 100.   X X X
Other scales:
- Tinetti test [66].
- Activities-Specific Balance Confidence Scale (ABC) [67].
- Timed up and go [68].
  X X X
Neuroimaging f Three whole-brain sequences:
- High-resolution T1-weighted magnetic resonance image (MRI).
- Resting-state functional magnetic resonance images (RS-fMRI)
- Diffusion tensor-based images (DTI).
- Axial T2 and Flair sequences to detect infarcts and white-matter alterations.
  X   X
Gut microbiome 16S analysis from stool samples [69].   X X X
Biomarkers Six inflammatory biomarkers, IL-2, IL-6, IL-10, TNFα, SAP and CRP [70,71,72,73,74].   X   X
Genetic study Family pedigree through a questionnaire in accordance to Goldman criteria [75].   X   
Candidate genes associated with neurodegenerative diseases (ApoE, TREM2 and MAPT) using real time PCR analysis.   X   
Genome-Wide Association Study (GWAS) [76].   X   
  1. a This module used standard items taken from previous studies [34]
  2. b Chile has its own prices to valuate health states using EQ5D [32, 77]. Items for tabacum consumption, physical activity, sedentarism, diet evaluation were taken from the National Health Survey 2009–2010, many of them in accordance to PAHO monitoring instruments [34]. AUDIT instrument has been validated in Chile [33]. Health inventory includes items for diagnosis, past and current treatment [78]. Operational measure of frailty includes a brief 5 items scale: unintentional weight loss, weakness, exhaustion, slow gait, and low physical activity [79, 80]. Framingham scale (validated in Chile) includes diabetes, hypertension, dyslipidemia, tabacum consumption, male gender and age as risk factor of cardiovascular disease [81]
  3. c Instruments previously validated for the Chilean population. Instruments developed by GERO (engagement in stimulating activities, aging related losses and social integration) and validated in a pilot study with a sample of 250 elderlies
  4. d AD8 has been validated in Chile [82]
  5. e Balance is evaluated using a Bertec FP4060–05-PT force platform (Bertec Corporation, Columbus, Ohio, USA). Electro-cardio-physiological and electrodermal activity is collected through a BIOPAC MP150 device (BIOPAC Systems Inc., Goleta, CA, USA). A custom-made MATLAB script is used to present the stimuli and send triggers to the AcqKnowledge software (BIOPAC) in sync with the onset of the stimuli
  6. f For a more detailed information of the neuroimaging protocol see Additional file 1