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Table 3 Risk factors for the development of early post-transplant infection in older recipients

From: Epidemiology, risk factors, and clinical impact of early post-transplant infection in older kidney transplant recipients: the Korean organ transplantation registry study

≥ 60 year-old Univariate Multivariate
HR (95% CI) p HR (95% CI) p
Sex, female 1.548 (1.119–2.142) 0.008 1.398 (1.199–1.631) <  0.001
BMI (kg/m2) 0.991 (0.939–1.046) 0.741   
Cause of ESRD
 Diabetes mellitus 1    
 Hypertension 0.898 (0.554–1.454) 0.661   
 Glomerulonephritis 1.192 (0.767–1.854) 0.436   
 ADPKD 0.781 (0.334–1.823) 0.568   
 Others 1.135 (0.452–2.850) 0.787   
 Unknown 1.226 (0.778–1.932) 0.379   
Duration of dialysis (month) 1.003 (1.001–1.005) 0.004 1.001 (1.000–1.002) 0.156
Diabetes mellitus 0.880 (0.635–1.219) 0.441   
Hypertension 0.663 (0.375–1.172) 0.157   
Cardiovascular disease 0.931 (0.627–1.384) 0.725   
Creatinine, baseline (mg/dL) 0.988 (0.935–1.045) 0.680   
Creatinine, discharge (mg/dL) 1.153 (0.945–1.408) 0.161   
Re-transplantation 0.994 (0.520–1.901) 0.986   
Deceased donor 1.495 (1.076–2.077) 0.017 1.364 (1.137–1.637) 0.001
Donor age (year) 1.022 (1.009–1.034) 0.001 1.010 (1.004–1.016) 0.001
Donor sex, female 1.204 (0.864–1.677) 0.273   
Desensitization 1.257 (0.849–1.859) 0.253   
ABO incompatibility 1.050 (0.662–1.667) 0.836   
Presence of DSA 1.324 (0.749–2.340) 0.334   
Length of hospitalization after KT (day) 1.016 (1.008–1.025) <  0.001 1.010 (1.006–1.014) <  0.001
Induction immunosuppression
No use 1   1  
 Basiliximab 1.513 (0.373–6.134) 0.562 2.051 (0.916–4.593) 0.081
 ATG 2.022 (0.489–8.357) 0.331 2.131 (0.941–4.827) 0.070
 Basiliximab + ATG 5.087 (0.987–26.223) 0.052 2.138 (0.851–5.370) 0.106
Calcineurin inhibitors
 No use 1    
 Tacrolimus 3.285 (0.460–23.478) 0.236   
 Cyclosporine 0.495 (0.031–7.913) 0.619   
Steroid 0.974 (0.361–2.631) 0.958   
Acute rejection 3.377 (2.399–4.754)   2.907 (2.471–3.419) <  0.001
  1. BMI body mass index, ESRD end stage renal disease, ADPKD autosomal dominant polycystic kidney disease, DSA donor specific antibody, KT kidney transplantation, ATG anti-thymocyte globulin